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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 13 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
3 SER UP Combined
104 SER UP, PRIDE Combined yes
105 SER PRIDE yes
202 TYR PRIDE yes
256 SER PRIDE yes
275 TYR UP, PRIDE Combined yes
287 THR UP, PRIDE Combined yes
295 SER UP, PRIDE Combined yes
305 SER PRIDE yes
345 SER UP, PRIDE Similarity yes
346 THR PRIDE yes
348 SER PRIDE yes
481 TYR PRIDE yes

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 17 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
104 103 114 2 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 9 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
105 102 114 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
105 103 114 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
202 187 204 16 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
256 247 260 10 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
275 265 281 11 5
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 24 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004415 27 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte -
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
PXD002286 3 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
287 282 302 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
287 284 302 4 8
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 158 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004415 34 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte
PXD003531 8 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004940 11 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD005366 71 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 48 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
295 283 302 13 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
295 284 302 12 8
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 161 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004415 21 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte -
PXD003531 22 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
PXD004940 13 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD006482 5 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD002286 6 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 17 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 21 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
305 303 310 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
345 335 353 11 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
345 344 352 2 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
346 344 352 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 19 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD004452 3 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
346 344 353 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
348 344 352 5 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 7 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
481 472 493 10 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain

Structures

Showing 7 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
4KXV A X-ray 0.9700000286102295 2 A 0.7743648 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 90.40808868408203 0.0
104 104 SER C 0.75 97.21701049804688 0.7824332118034363
105 105 SER C 1.0 10.17042350769043 4.880915641784668
202 202 TYR H 1.0 10.154730796813965 0.0
256 256 SER C 1.0 103.6208724975586 1.3388267755508423
275 275 TYR H 0.92 110.46725463867188 0.0
287 287 THR C 0.67 56.296573638916016 0.0
295 295 SER C 0.61 117.33683013916016 0.0
305 305 SER C 0.53 67.04712677001953 0.0
342 342 THR C 0.8 21.828569412231445 7.443739414215088
345 345 SER H 0.83 26.56473731994629 8.424694061279297
346 346 THR H 1.0 1.287216067314148 0.0
348 348 SER C 1.0 0.0 0.0
481 481 TYR C 1.0 12.862133026123047 0.0
4KXW A X-ray 0.9700000286102295 2 A 0.5379441 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 90.94644927978516 0.0
104 104 SER C 0.75 96.51937103271484 0.7824332118034363
105 105 SER C 1.0 10.17042350769043 4.880915641784668
202 202 TYR H 1.0 10.309065818786621 0.0
256 256 SER C 1.0 103.59627532958984 0.0
275 275 TYR H 0.92 117.3469467163086 0.0
287 287 THR E 0.67 57.85048294067383 0.0
295 295 SER C 0.61 116.04080200195312 0.0
305 305 SER C 0.53 66.78863525390625 0.0
342 342 THR C 0.8 20.96732521057129 6.738316059112549
345 345 SER H 0.83 21.592885971069336 3.8418965339660645
346 346 THR H 1.0 1.286739706993103 0.0
348 348 SER H 1.0 0.0 0.0
481 481 TYR C 1.0 12.342455863952637 0.0
4KXU A X-ray 0.9800000190734863 2 A 0.58263135 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 86.56320190429688 0.0
104 104 SER C 0.75 97.69678497314453 0.7824332118034363
105 105 SER C 1.0 9.658045768737793 4.343520164489746
202 202 TYR H 1.0 10.154730796813965 0.0
256 256 SER C 1.0 103.25138092041016 0.0
275 275 TYR H 0.92 116.50199890136719 0.0
287 287 THR E 0.67 58.245906829833984 0.0
295 295 SER C 0.61 115.30958557128906 0.0
305 305 SER C 0.53 67.14810943603516 0.0
342 342 THR C 0.8 22.995113372802734 7.210450649261475
345 345 SER H 0.83 25.60441017150879 5.687307357788086
346 346 THR H 1.0 1.7014838457107544 0.0
348 348 SER C 1.0 0.0 0.0
481 481 TYR C 1.0 12.737383842468262 0.0
4KXX A X-ray 1.0299999713897705 2 A 0.7153896 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 80.35542297363281 0.0
104 104 SER C 0.75 96.83153533935547 0.7824332118034363
105 105 SER C 1.0 9.828801155090332 4.844932556152344
202 202 TYR H 1.0 10.35132122039795 0.0
256 256 SER C 1.0 101.35719299316406 0.0
275 275 TYR H 0.92 107.16149139404297 0.0
287 287 THR C 0.67 55.78693389892578 0.0
295 295 SER C 0.61 115.31886291503906 0.0
305 305 SER C 0.53 66.4608383178711 0.0
342 342 THR C 0.8 22.480907440185547 8.030341148376465
345 345 SER H 0.83 23.959367752075195 6.430959701538086
346 346 THR H 1.0 1.2854044437408447 0.0
348 348 SER H 1.0 0.3258882462978363 0.0
481 481 TYR C 1.0 12.035212516784668 0.0
4KXY A X-ray 1.2599999904632568 2 B 0.4360522 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 88.19928741455078 0.0
104 104 SER C 0.75 96.61479187011719 0.6229763031005859
105 105 SER C 1.0 9.665563583374023 4.850252151489258
202 202 TYR H 1.0 10.822044372558594 0.0
256 256 SER C 1.0 100.5892105102539 0.0
275 275 TYR H 0.92 126.45220184326172 0.0
287 287 THR E 0.67 56.133155822753906 0.0
295 295 SER C 0.61 107.76626586914062 0.0
305 305 SER C 0.53 65.76347351074219 0.0
342 342 THR C 0.8 23.519447326660156 7.641857147216797
345 345 SER H 0.83 22.21414566040039 8.097982406616211
346 346 THR H 1.0 1.5326176881790161 0.0
348 348 SER H 1.0 0.1679818332195282 0.0
481 481 TYR C 1.0 12.08874797821045 0.0
3MOS A X-ray 1.75 2 A 0.60194606 3, 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
3 3 SER C 0.3 150.8783416748047 0.0
104 104 SER C 0.75 97.9420394897461 0.9389395117759705
105 105 SER C 1.0 8.903162002563477 4.751635551452637
202 202 TYR H 1.0 9.480685234069824 0.0
256 256 SER C 1.0 98.84797668457031 0.0
275 275 TYR H 0.92 119.85427856445312 0.0
287 287 THR E 0.67 62.564422607421875 0.0
295 295 SER C 0.61 114.59710693359375 0.0
305 305 SER C 0.53 65.25411987304688 0.0
342 342 THR C 0.8 22.307634353637695 7.70078706741333
345 345 SER H 0.83 19.9773006439209 7.982104301452637
346 346 THR H 1.0 0.9503349661827087 0.0
348 348 SER H 1.0 0.3258882462978363 0.0
481 481 TYR C 1.0 9.594865798950195 0.0
3OOY A X-ray 2.049999952316284 2 B 0.6370711 104, 105, 202, 256, 275, 287, 295, 305, 345, 346, 348, 481
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
104 104 SER C 0.75 97.8708724975586 0.15650628507137299
105 105 SER C 1.0 8.132532119750977 3.901702404022217
202 202 TYR H 1.0 9.572303771972656 0.0
256 256 SER C 1.0 107.97795867919922 0.0
275 275 TYR H 0.92 130.78192138671875 0.0
287 287 THR E 0.67 63.025482177734375 0.0
295 295 SER C 0.61 113.09574127197266 0.0
305 305 SER C 0.53 67.02787780761719 0.0
342 342 THR C 0.8 21.934795379638672 7.481957912445068
345 345 SER H 0.83 22.084915161132812 8.078276634216309
346 346 THR H 1.0 0.9517345428466797 0.0
348 348 SER C 1.0 0.6616836190223694 0.0
481 481 TYR C 1.0 12.0961275100708 0.0

Mutations

Showing 2 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
181 I V Polymorphism
318 R C Disease Short stature, developmental delay, and congenital heart defects (SDDHD) [MIM:617044]