Welcome to Scop3P

Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

DDX3X_HUMAN : ATP-dependent RNA helicase DDX3X

Zoom in and zoom out (both with mouse and buttons on the right top corner) to see modificationson the protein
Slide the chart to see other modifications (both with mouse and buttons on the right topcorner)
Hover on the modification to see more information and position on the structure.

PDB

AlphaFold

Phospho-sites

Showing 37 results

Swiss-Prot Position	Modification	Source	Evidence	Singly phosphorylated
53	TYR	PRIDE		yes
61	SER	PRIDE		yes
69	TYR	PRIDE		yes
70	SER	PRIDE		yes
71	SER	PRIDE		yes
74	SER	PRIDE		yes
82	SER	UP, PRIDE	Combined
83	SER	PRIDE
86	SER	UP, PRIDE	Combined	yes
90	SER	UP, PRIDE	Combined	yes
92	SER	PRIDE		yes
102	SER	UP, PRIDE	Experimental	yes
104	TYR	UP, PRIDE	Similarity	yes
131	SER	UP, PRIDE	Combined	yes
152	SER	PRIDE		yes
156	THR	PRIDE		yes
183	SER	UP	Combined
204	THR	PRIDE		yes
266	TYR	PRIDE		yes
301	TYR	PRIDE		yes
343	TYR	PRIDE		yes
369	THR	PRIDE		yes
410	SER	PRIDE		yes
411	THR	PRIDE		yes
456	SER	UP	Similarity
492	SER	PRIDE		yes
508	SER	PRIDE		yes
520	SER	PRIDE		yes
591	SER	PRIDE		yes
594	SER	UP, PRIDE	Combined	yes
605	SER	UP, PRIDE	Combined	yes
606	SER	PRIDE		yes
609	SER	PRIDE		yes
612	SER	UP, PRIDE	Combined	yes
614	SER	PRIDE		yes
616	SER	PRIDE		yes
619	SER	PRIDE		yes

Swiss-Prot Position

Modification

Source

Evidence

Singly phosphorylated

TYR

PRIDE

yes

SER

PRIDE

yes

TYR

PRIDE

yes

SER

PRIDE

yes

SER

PRIDE

yes

SER

PRIDE

yes

SER

UP, PRIDE

Combined

SER

PRIDE

SER

UP, PRIDE

Combined

yes

SER

UP, PRIDE

Combined

yes

SER

PRIDE

yes

102

SER

UP, PRIDE

Experimental

yes

104

TYR

UP, PRIDE

Similarity

yes

131

SER

UP, PRIDE

Combined

yes

152

SER

PRIDE

yes

156

THR

PRIDE

yes

183

SER

Combined

204

THR

PRIDE

yes

266

TYR

PRIDE

yes

301

TYR

PRIDE

yes

343

TYR

PRIDE

yes

369

THR

PRIDE

yes

410

SER

PRIDE

yes

411

THR

PRIDE

yes

456

SER

Similarity

492

SER

PRIDE

yes

508

SER

PRIDE

yes

520

SER

PRIDE

yes

591

SER

PRIDE

yes

594

SER

UP, PRIDE

Combined

yes

605

SER

UP, PRIDE

Combined

yes

606

SER

PRIDE

yes

609

SER

PRIDE

yes

612

SER

UP, PRIDE

Combined

yes

614

SER

PRIDE

yes

616

SER

PRIDE

yes

619

SER

PRIDE

yes

3D structure is not available

Display Settings

Style

Color

Show All P-sites

Spin

Hover over to see the values, zoom (in/out) or drag by using the mouse pointer.

Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 49 results

Sequence

Modified position (Swiss-Prot)

Peptide start

Peptide end

Modified position (Peptide)

Number of projects

GFYDKDSSGWSSSK

DSSGWSSSK

DKDAYSSFGSR

DAYSSFGSR

GKSSFFSDR

SSFFSDR

GKSSFFSDR

SSFFSDR

SSFFSDRGSGSR

FDDRGRSDYDGIGSR

102

110

GRSDYDGIGSR

102

100

110

GRSDYDGIGSR

104

100

110

GRSDYDGIGSRGDR

104

100

113

SDYDGIGSR

104

102

110

SDYDGIGSRGDR

104

102

113

WCDKSDEDDWSK

131

127

138

SDEDDWSK

131

138

PLPPSERLEQELFSGGNTGINFEK

152

139

162

LEQELFSGGNTGINFEK

152

146

162

LEQELFSGGNTGINFEK

156

146

162

YTRPTPVQK

204

200

208

RKQYPISLVLAPTR

266

263

276

KQYPISLVLAPTR

266

264

276

QYPISLVLAPTR

266

265

276

VRPCVVYGGADIGQQIR

301

295

311

IGLDFCKYLVLDEADR

343

336

351

MLDMGFEPQIRRIVEQDTMPPK

369

352

373

VGSTSENITQK

410

408

418

VGSTSENITQK

411

408

418

SGKSPILVATAVAAR

492

489

503

SPILVATAVAAR

492

503

GLDISNVK

508

504

511

HVINFDLPSDIEEYVHR

520

512

528

SSRFSGGFGAR

591

590

600

SSRFSGGFGAR

594

590

600

FSGGFGAR

594

593

600

DYRQSSGASSSSFSSSR

605

601

617

QSSGASSSSFSSSR

605

604

617

QSSGASSSSFSSSR

606

604

617

QSSGASSSSFSSSR

609

604

617

QSSGASSSSFSSSR

612

604

617

QSSGASSSSFSSSR

614

604

617

QSSGASSSSFSSSR

616

604

617

QSSGASSSSFSSSRASSSR

619

604

622

Structures

Showing 8 results

PDB id

Chain

Method

Resolution

Stoichiometry

Interfacing Molecule/Chain

Complex Formation Significance Score (CSS)

P-sites

View Structure

4PXA

X-ray

3.2

Monomer

[ADP]A:601

0.019979104

152, 156, 183, 204, 266, 301, 343, 369, 410, 411, 456, 492, 508, 520

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
152	152	SER	C	1.0	91.96669006347656	0.0
156	156	THR	C	1.0	109.18385314941406	34.476768493652344
183	183	SER	C	0.88	82.41026306152344	0.0
204	204	THR	C	1.0	10.458459854125977	10.122610092163086
266	266	TYR	C	0.9	44.361576080322266	0.0
301	301	TYR	C	1.0	30.53438377380371	0.0
343	343	TYR	E	1.0	11.60538101196289	0.0
369	369	THR	C	1.0	74.91482543945312	0.0
410	410	SER	C	1.0	29.11933708190918	0.0
411	411	THR	C	1.0	12.474488258361816	0.0
456	456	SER	H	0.88	55.335105895996094	0.0
492	492	SER	C	1.0	9.192042350769043	0.0
508	508	SER	C	1.0	31.25473976135254	0.0
520	520	SER	C	1.0	99.09168243408203	0.0
542	542	THR	E	1.0	6.943846702575684	0.0

5E7I

X-ray

2.22

Monomer

0.0

152, 183, 204, 266, 301, 343, 369, 410, 411, 456, 492, 508, 520

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
152	152	SER	C	1.0	93.6357192993164	0.0
183	183	SER	C	0.88	85.48359680175781	0.0
204	204	THR	C	1.0	45.94361114501953	0.0
266	266	TYR	C	0.9	39.511470794677734	0.0
301	301	TYR	C	1.0	32.162052154541016	20.315025329589844
343	343	TYR	E	1.0	13.938196182250977	0.0
369	369	THR	C	1.0	53.525203704833984	0.0
410	410	SER	C	1.0	44.029991149902344	0.0
411	411	THR	C	1.0	24.26247215270996	0.0
456	456	SER	H	0.88	39.14509582519531	0.0
492	492	SER	C	1.0	9.202756881713867	0.0
508	508	SER	C	1.0	27.460084915161133	0.0
520	520	SER	C	1.0	95.59954833984375	0.0
542	542	THR	E	1.0	5.988486289978027	0.0

5E7J

X-ray

2.23

Monomer

[AMP]A:801

0.1

152, 183, 204, 266, 301, 343, 369, 410, 411, 456, 492, 508, 520

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
152	152	SER	C	1.0	78.1178970336914	0.0
183	183	SER	H	0.88	83.1849594116211	0.0
204	204	THR	C	1.0	43.088417053222656	19.243080139160156
266	266	TYR	C	0.9	42.49167251586914	0.0
301	301	TYR	C	1.0	28.726491928100586	0.0
343	343	TYR	E	1.0	16.002588272094727	0.0
369	369	THR	C	1.0	54.10177993774414	0.0
410	410	SER	C	1.0	52.97726058959961	0.0
411	411	THR	C	1.0	53.7939567565918	0.0
456	456	SER	H	0.88	37.90646743774414	0.0
492	492	SER	C	1.0	12.888101577758789	0.0
508	508	SER	C	1.0	44.74981689453125	0.0
520	520	SER	C	1.0	89.94252014160156	0.0
542	542	THR	E	1.0	7.216723918914795	0.0

5E7M

X-ray

2.3

Monomer

[ANP]A:801

0.1

152, 183, 204, 266, 301, 343, 369, 410, 411, 456, 492, 508, 520

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
152	152	SER	C	1.0	104.69984436035156	0.0
183	183	SER	C	0.88	79.62234497070312	0.0
204	204	THR	C	1.0	37.39958190917969	17.401111602783203
266	266	TYR	C	0.9	48.55812454223633	0.0
301	301	TYR	C	1.0	30.200130462646484	0.0
343	343	TYR	E	1.0	6.880403995513916	0.0
369	369	THR	C	1.0	54.52661895751953	0.0
410	410	SER	C	1.0	63.29811096191406	0.0
411	411	THR	C	1.0	26.833139419555664	0.0
456	456	SER	H	0.88	43.44511795043945	0.0
492	492	SER	C	1.0	4.783890247344971	0.0
508	508	SER	C	1.0	13.079737663269043	0.0
520	520	SER	C	1.0	86.13318634033203	0.0
542	542	THR	E	1.0	1.5671350955963135	0.0

2I4I

X-ray

2.2

[AMP]A:600

0.1

183, 204, 266, 301, 343, 369, 411, 456, 492, 508, 520

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
183	183	SER	H	0.88	77.29350280761719	0.0
204	204	THR	C	1.0	40.74525451660156	18.312358856201172
266	266	TYR	C	0.9	36.817787170410156	0.0
301	301	TYR	C	1.0	32.086761474609375	0.0
343	343	TYR	E	1.0	22.61629295349121	0.0
369	369	THR	C	1.0	54.548667907714844	0.0
411	411	THR	C	1.0	60.40039825439453	0.0
456	456	SER	H	0.88	52.52967071533203	0.0
492	492	SER	C	1.0	6.313713073730469	0.0
508	508	SER	C	1.0	31.48214340209961	0.0
520	520	SER	C	1.0	95.37239837646484	0.0
542	542	THR	E	1.0	3.2981467247009277	0.0

4PX9

X-ray

2.31

Monomer

[ADP]A:601

0.1

183, 204, 266, 301, 343, 369

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
183	183	SER	H	0.88	82.51119995117188	0.0
204	204	THR	C	1.0	46.16703414916992	17.54050636291504
266	266	TYR	C	0.9	49.1619987487793	0.0
301	301	TYR	C	1.0	26.821395874023438	0.0
343	343	TYR	E	1.0	17.109600067138672	0.0
369	369	THR	C	1.0	54.59788513183594	0.0

3JRV

X-ray

1.6

1.0

82, 83, 86

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
82	82	SER	C	0.86	109.2723617553711	69.30858612060547
83	83	SER	C	1.0	49.21985626220703	47.9929313659668
86	86	SER	C	0.49	125.16642761230469	77.04280090332031

2JGN

X-ray

1.91

Monomer

0.0

Swiss-Prot position	PDB position	Residue	Secondary Structure	Conserved Scale	Accessible surface area	Buried surface area
411	410	THR	C	1.0	136.18142700195312	0.0
456	455	SER	H	0.88	44.32827377319336	0.0
492	491	SER	C	1.0	3.7611196041107178	0.0
508	507	SER	C	1.0	84.88955688476562	0.0
520	519	SER	C	1.0	81.36082458496094	0.0
542	541	THR	E	1.0	6.705598831176758	4.126954555511475

Mutations

Showing 19 results

Swiss-Prot Position

Amino acid (Wild type)

Amino acid (Variant)

Variant Type

Disease

214

Disease