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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 20 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
8 SER PRIDE yes
11 TYR PRIDE yes
17 SER UP, PRIDE Combined yes
26 SER UP, PRIDE Combined yes
42 SER PRIDE yes
198 THR PRIDE yes
207 SER PRIDE yes
225 SER UP, PRIDE Combined yes
361 TYR PRIDE yes
389 THR UP, PRIDE Combined yes
393 THR PRIDE yes
457 SER PRIDE yes
709 TYR UP Similarity
756 SER PRIDE yes
835 SER PRIDE yes
1428 THR UP, PRIDE Combined yes
1765 THR UP Similarity
2000 THR PRIDE yes
2002 SER UP, PRIDE Combined yes
2075 SER PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 20 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
8 8 14 1 5
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 8 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD003531 11 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
11 8 14 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 8 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
17 15 25 3 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 10 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 3 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
26 15 30 12 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 21 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004452 4 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
42 34 46 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
198 187 221 12 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000680 2 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
207 187 221 21 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 15 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD000680 4 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
225 222 237 4 16
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004252 38 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD000474 20 Simulated phosphopeptide spectral library for confident site localization Homo sapiens (Human) PARTIAL 2015-03-17 HeLa cell
PXD004447 3 Mirroring the charged termini; ETD/HCD fragmentation characteristics of LysargiNase and tryptic peptides and their benefits for peptide sequencing in proteomics Homo sapiens (Human) PARTIAL 2016-12-02 cell culture -
PXD003531 266 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004940 13 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD001333 48 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD002286 1278 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD006482 10 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD005366 278 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 99 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD002394 14 Proteomic and phosphoproteomic analysis of cisplatin resistance in patient derived serous ovarian cancer Homo sapiens (Human) PARTIAL 2017-05-02 cell suspension culture -
PXD001550 188 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD000680 233 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
PXD000836 29 HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies Homo sapiens (Human) PARTIAL 2014-05-22 lung -
PXD000612 442 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001546 26 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
361 359 368 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
389 387 406 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD002286 2 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD004452 2 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
393 387 406 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
457 441 466 17 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
457 452 466 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
457 454 466 4 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 28 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD003531 7 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004452 3 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
756 754 763 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
835 830 838 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 20 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1428 1422 1431 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
2000 1994 2009 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
2002 1994 2009 9 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 6 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD004452 5 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD000680 2 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
2075 2073 2080 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture

Structures

Showing 9 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
4F92 B X-ray 2.6600000858306885 Monomer B 0.0 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 117.39215087890625 0.0
709 709 TYR H 1.0 27.069805145263672 0.0
756 756 SER C 1.0 78.25841522216797 0.0
834 834 TYR E 1.0 29.540809631347656 0.0
835 835 SER E 1.0 8.405906677246094 0.0
1428 1428 THR C 1.0 7.413575172424316 0.0
1765 1765 THR H 1.0 55.986141204833984 0.0
2000 2000 THR C 0.82 58.47494125366211 0.0
2002 2002 SER H 0.0 73.20764923095703 0.0
2075 2075 SER E 1.0 35.05570983886719 0.0
4F91 B X-ray 2.700000047683716 Monomer B 0.0 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 114.68678283691406 0.0
709 709 TYR H 1.0 54.52528762817383 0.0
756 756 SER C 1.0 57.393836975097656 0.0
834 834 TYR E 1.0 23.635927200317383 0.0
835 835 SER E 1.0 14.123342514038086 0.0
1428 1428 THR C 1.0 5.700507164001465 0.0
1765 1765 THR H 1.0 36.209041595458984 0.0
2000 2000 THR C 0.82 56.66453170776367 0.0
2002 2002 SER H 0.0 70.38240051269531 0.0
2075 2075 SER E 1.0 33.08865737915039 0.0
5URJ A X-ray 2.75 2 A 0.7235806 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 109.16523742675781 0.0
709 709 TYR H 1.0 47.91398239135742 0.0
756 756 SER C 1.0 68.49117279052734 0.0
834 834 TYR E 1.0 29.17816734313965 0.0
835 835 SER E 1.0 16.48411750793457 0.0
1428 1428 THR C 1.0 11.566720962524414 0.0
1765 1765 THR H 1.0 43.39608383178711 0.0
2000 2000 THR C 0.82 57.99852752685547 0.0
2002 2002 SER H 0.0 66.32647705078125 0.0
2075 2075 SER E 1.0 33.35274887084961 0.0
5URM A X-ray 2.799999952316284 2 B 0.82669467 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 112.47577667236328 0.0
709 709 TYR H 1.0 26.00984764099121 0.0
756 756 SER C 1.0 57.05476760864258 0.0
834 834 TYR E 1.0 19.54714584350586 0.0
835 835 SER E 1.0 16.27439308166504 0.0
1428 1428 THR C 1.0 14.377914428710938 0.0
1765 1765 THR H 1.0 42.982723236083984 0.0
2000 2000 THR C 0.82 52.26782989501953 0.0
2002 2002 SER H 0.0 65.62503814697266 0.0
2075 2075 SER E 1.0 38.59255599975586 0.0
4F93 B X-ray 2.9200000762939453 2 B 0.27849054 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 121.2884750366211 0.0
709 709 TYR H 1.0 26.82475471496582 0.0
756 756 SER C 1.0 104.39454650878906 0.0
834 834 TYR E 1.0 25.681699752807617 0.0
835 835 SER E 1.0 21.285924911499023 0.0
1428 1428 THR C 1.0 6.1832499504089355 0.0
1765 1765 THR H 1.0 57.23249053955078 0.0
2000 2000 THR C 0.82 68.4063491821289 0.0
2002 2002 SER H 0.0 76.54659271240234 0.0
2075 2075 SER E 1.0 36.86580276489258 0.0
5URK A X-ray 2.950000047683716 Monomer A 0.0 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 119.56800079345703 30.004592895507812
709 709 TYR H 1.0 51.12025451660156 0.0
756 756 SER C 1.0 86.46642303466797 0.0
834 834 TYR E 1.0 36.04677200317383 0.0
835 835 SER E 1.0 16.733060836791992 0.0
1428 1428 THR C 1.0 1.651120901107788 0.0
1765 1765 THR H 1.0 45.82267761230469 0.0
2000 2000 THR C 0.82 71.64929962158203 0.0
2002 2002 SER H 0.0 80.28680419921875 0.0
2075 2075 SER E 1.0 38.0599365234375 0.0
4KIT B X-ray 3.5999999046325684 2 C 0.4293453 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 111.64892578125 0.0
709 709 TYR H 1.0 20.02640724182129 0.0
756 756 SER C 1.0 78.39903259277344 0.0
834 834 TYR E 1.0 35.71315002441406 0.0
835 835 SER E 1.0 20.467945098876953 0.0
1428 1428 THR C 1.0 9.630807876586914 0.0
1765 1765 THR C 1.0 37.72409439086914 0.0
2000 2000 THR C 0.82 34.4024543762207 0.0
2002 2002 SER H 0.0 76.18305969238281 0.0
2075 2075 SER E 1.0 33.16374588012695 0.0
5O9Z C EM 4.5 Monomer 4 0.0 457, 709, 756, 835, 1428, 1765, 2000, 2002, 2075
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
457 457 SER C 0.73 107.68598937988281 0.0
709 709 TYR H 1.0 39.52029800415039 0.0
756 756 SER C 1.0 107.79988098144531 0.0
834 834 TYR E 1.0 89.32952117919922 58.835758209228516
835 835 SER C 1.0 19.54244041442871 2.8359410762786865
1428 1428 THR C 1.0 34.94288635253906 0.0
1765 1765 THR H 1.0 73.3289794921875 0.0
2000 2000 THR C 0.82 71.01456451416016 0.0
2002 2002 SER H 0.0 82.32708740234375 0.0
2075 2075 SER E 1.0 45.904945373535156 0.0
2Q0Z X X-ray 2.0 Monomer X 0.0
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
2000 193 THR C 0.82 81.57691955566406 0.0
2002 195 SER H 0.0 81.9170913696289 0.0
2075 268 SER E 1.0 40.91672897338867 0.0

Mutations

Showing 13 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
502 C R Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
542 A V Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
681 R C Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
682 P S Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
683 V L Unclassified Retinitis pigmentosa 33 (RP33) [MIM:610359]
689 Y C Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
698 I V Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
885 Q E Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
1087 S L Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
1090 R L Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
1736 F L Unclassified A colorectal cancer sample
1779 R H Disease Retinitis pigmentosa 33 (RP33) [MIM:610359]
1995 A T Polymorphism