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Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

CDK12_HUMAN : Cyclin-dependent kinase 12

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PDB 
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Phospho-sites

Showing 71 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
14 SER PRIDE yes
25 SER PRIDE yes
29 SER PRIDE
30 SER PRIDE yes
32 SER PRIDE yes
57 THR UP, PRIDE Combined yes
154 SER PRIDE yes
220 SER PRIDE
222 SER PRIDE
228 SER PRIDE yes
231 SER PRIDE yes
236 SER UP, PRIDE Combined
238 SER PRIDE yes
246 TYR PRIDE
249 SER UP, PRIDE Combined
256 SER PRIDE yes
261 SER PRIDE yes
262 TYR PRIDE yes
268 SER PRIDE
269 THR PRIDE
274 SER UP, PRIDE Combined
276 SER UP, PRIDE Combined
279 TYR PRIDE
285 TYR PRIDE yes
287 SER PRIDE yes
291 SER PRIDE
293 SER PRIDE
301 SER UP, PRIDE Combined
303 SER UP, PRIDE Combined
318 SER UP, PRIDE Combined
319 TYR PRIDE
320 SER PRIDE
323 SER UP, PRIDE Combined
325 SER UP, PRIDE Combined
332 SER UP, PRIDE Combined
333 SER UP, PRIDE Combined
334 SER UP, PRIDE Combined
341 SER UP, PRIDE Combined yes
343 SER UP, PRIDE Combined
345 SER UP, PRIDE Combined
357 SER PRIDE
359 SER PRIDE
379 SER PRIDE yes
382 SER PRIDE
383 SER UP, PRIDE Combined
385 SER UP, PRIDE Combined
420 SER UP, PRIDE Combined yes
423 SER UP, PRIDE Combined yes
440 SER PRIDE yes
514 THR UP, PRIDE Combined yes
614 SER UP, PRIDE Combined yes
644 SER UP, PRIDE Similarity yes
681 SER UP, PRIDE Combined
685 SER UP, PRIDE Combined
692 THR UP, PRIDE Combined yes
889 SER UP Combined
893 THR UP, PRIDE Combined yes
1053 SER UP, PRIDE Combined yes
1071 THR PRIDE yes
1072 SER PRIDE yes
1075 SER PRIDE yes
1076 THR PRIDE yes
1082 SER PRIDE yes
1083 SER UP, PRIDE Combined yes
1220 THR PRIDE
1226 SER PRIDE yes
1232 SER PRIDE yes
1236 SER PRIDE
1244 THR UP, PRIDE Combined yes
1246 THR UP, PRIDE Similarity yes
1440 TYR PRIDE yes

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 127 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
DGSGGASGTLQPSSGGGSSNSR 14 12 33 3 1
DGSGGASGTLQPSSGGGSSNSR 25 12 33 14 2
DGSGGASGTLQPSSGGGSSNSRER 25 12 35 14 1
DGSGGASGTLQPSSGGGSSNSR 29 12 33 18 2
DGSGGASGTLQPSSGGGSSNSR 30 12 33 19 1
DGSGGASGTLQPSSGGGSSNSRER 32 12 35 21 1
DMGLVTPEAASLGTVIK 57 52 68 6 4
SNEETDDYGK 154 154 163 1 1
SRSPHR 220 220 225 1 1
SRSPHR 222 220 225 3 1
KWSDSSK 228 226 232 3 1
WSDSSK 228 227 232 2 1
KWSDSSKQDDSPSGASYGQDYDLSPSR 231 226 252 6 1
QDDSPSGASYGQDYDLSPSRSHTSSNYDSYKK 236 233 264 4 1
QDDSPSGASYGQDYDLSPSR 236 233 252 4 5
QDDSPSGASYGQDYDLSPSRSHTSSNYDSYK 236 233 263 4 1
QDDSPSGASYGQDYDLSPSR 238 233 252 6 1
QDDSPSGASYGQDYDLSPSRSHTSSNYDSYK 246 233 263 14 1
QDDSPSGASYGQDYDLSPSRSHTSSNYDSYKK 246 233 264 14 1
QDDSPSGASYGQDYDLSPSRSHTSSNYDSYK 249 233 263 17 1
QDDSPSGASYGQDYDLSPSR 249 233 252 17 1
SHTSSNYDSYK 256 253 263 4 1
SHTSSNYDSYKK 261 253 264 9 2
SHTSSNYDSYKKSPGSTSR 262 253 271 10 1
KSPGSTSRR 268 264 272 5 1
KSPGSTSRR 269 264 272 6 1
SPGSTSRRQSVSPPYK 274 265 280 10 1
RQSVSPPYKEPSAYQSSTR 274 272 290 3 7
RQSVSPPYK 274 272 280 3 3
RQSVSPPYKEPSAYQSSTR 276 272 290 5 9
RQSVSPPYK 276 272 280 5 3
QSVSPPYK 276 273 280 4 2
RQSVSPPYKEPSAYQSSTR 279 272 290 8 2
EPSAYQSSTRSPSPYSR 285 281 297 5 1
EPSAYQSSTRSPSPYSR 287 281 297 7 1
EPSAYQSSTRSPSPYSR 291 281 297 11 2
SPSPYSR 291 291 297 1 3
EPSAYQSSTRSPSPYSR 293 281 297 13 3
SPSPYSR 293 291 297 3 3
RQRSVSPYSR 301 298 307 4 2
QRSVSPYSR 301 299 307 3 4
SVSPYSR 301 301 307 1 7
RQRSVSPYSR 303 298 307 6 2
QRSVSPYSR 303 299 307 5 4
SVSPYSR 303 301 307 3 10
SGSYSGRSPSPYGR 318 316 329 3 1
SGSYSGRSPSPYGR 319 316 329 4 2
SGSYSGRSPSPYGR 320 316 329 5 2
SGSYSGRSPSPYGR 323 316 329 8 7
SGSYSGRSPSPYGR 325 316 329 10 9
SGSYSGRSPSPYGRR 325 316 330 10 1
SPSPYGR 325 323 329 3 2
RRSSSPFLSK 332 330 339 3 8
RSSSPFLSK 332 331 339 2 2
SSSPFLSK 332 332 339 1 4
SSSPFLSKR 332 332 340 1 2
RRSSSPFLSK 333 330 339 4 9
RSSSPFLSKR 333 331 340 3 2
RSSSPFLSK 333 331 339 3 2
SSSPFLSKR 333 332 340 2 10
SSSPFLSK 333 332 339 2 9
RRSSSPFLSK 334 330 339 5 9
RSSSPFLSKR 334 331 340 4 2
RSSSPFLSK 334 331 339 4 3
SSSPFLSK 334 332 339 3 13
SSSPFLSKR 334 332 340 3 12
SLSRSPLPSR 341 341 350 1 1
RSLSRSPLPSR 343 340 350 4 1
SLSRSPLPSR 343 341 350 3 6
SLSRSPLPSRK 343 341 351 3 2
RSLSRSPLPSR 345 340 350 6 1
SLSRSPLPSRK 345 341 351 5 3
SLSRSPLPSR 345 341 350 5 5
SRSRSPAYSR 357 355 364 3 1
SRSRSPAYSR 359 355 364 5 3
SRHSSISPVRLPLNSSLGAELSR 379 379 401 1 1
SRHSSISPVRLPLNSSLGAELSR 382 379 401 4 2
HSSISPVRLPLNSSLGAELSR 382 381 401 2 1
SRHSSISPVRLPLNSSLGAELSR 383 379 401 5 7
HSSISPVRLPLNSSLGAELSRK 383 381 402 3 5
HSSISPVRLPLNSSLGAELSR 383 381 401 3 13
HSSISPVR 383 381 388 3 2
SRHSSISPVRLPLNSSLGAELSR 385 379 401 7 8
HSSISPVRLPLNSSLGAELSR 385 381 401 5 14
HSSISPVRLPLNSSLGAELSRK 385 381 402 5 4
HSSISPVR 385 381 388 5 3
MDGKESKGSPVFLPR 420 415 429 6 2
ESKGSPVFLPR 420 419 429 2 6
MDGKESKGSPVFLPR 423 415 429 9 5
ESKGSPVFLPR 423 419 429 5 12
ESKGSPVFLPRK 423 419 430 5 1
GSPVFLPR 423 422 429 2 16
GSPVFLPRK 423 422 430 2 3
ENSSVEAKDSGLESK 440 431 445 10 1
DSKPIALKEEIVTPK 514 502 516 13 5
EEIVTPK 514 510 516 5 6
EEIVTPKETETSEK 514 510 523 5 1
TQVSVTAAIPHLK 614 611 623 4 1
TSTLPPLPLPPLLPGDDDMDSPK 644 624 646 21 4
TSTLPPLPLPPLLPGDDDMDSPKETLPSKPVK 644 624 655 21 2
TSTLPPLPLPPLLPGDDDMDSPKETLPSK 644 624 652 21 1
TRHLLTDLPLPPELPGGDLSPPDSPEPK 681 662 689 20 4
HLLTDLPLPPELPGGDLSPPDSPEPK 681 664 689 18 10
TRHLLTDLPLPPELPGGDLSPPDSPEPK 685 662 689 24 4
HLLTDLPLPPELPGGDLSPPDSPEPK 685 664 689 22 10
AITPPQQPYKK 692 690 700 3 7
AITPPQQPYK 692 690 699 3 14
LYNSEESRPYTNK 893 883 895 11 2
QRQSGVVVEEPPPSK 1053 1050 1064 4 2
ETTSGTSTEPVK 1071 1069 1080 3 1
ETTSGTSTEPVK 1072 1069 1080 4 1
ETTSGTSTEPVK 1075 1069 1080 7 2
ETTSGTSTEPVK 1076 1069 1080 8 1
ETTSGTSTEPVKNSSPAPPQPAPGK 1082 1069 1093 14 1
NSSPAPPQPAPGK 1082 1081 1093 2 1
KETTSGTSTEPVKNSSPAPPQPAPGK 1083 1068 1093 16 6
ETTSGTSTEPVKNSSPAPPQPAPGK 1083 1069 1093 15 4
NSSPAPPQPAPGK 1083 1081 1093 3 14
TQEPAGSLEENNSDKNSGPQGPR 1220 1220 1242 1 1
TQEPAGSLEENNSDK 1226 1220 1234 7 1
TQEPAGSLEENNSDK 1232 1220 1234 13 1
TQEPAGSLEENNSDKNSGPQGPR 1236 1220 1242 17 1
RTPTMPQEEAAACPPHILPPEK 1244 1243 1264 2 6
TPTMPQEEAAACPPHILPPEK 1244 1244 1264 1 1
NSGPQGPRRTPTMPQEEAAACPPHILPPEK 1246 1235 1264 12 1
RTPTMPQEEAAACPPHILPPEK 1246 1243 1264 4 1
LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK 1440 1437 1470 4 1

Structures

Showing 5 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
4NST A X-ray 2.2 Monomer [ADP]A:1101 0.02881599 889
5ACB C X-ray 2.7 2 B 0.5517995 889
6B3E A X-ray 3.06 2 B 0.76444393 889
4UN0 C X-ray 3.15 2 A 1.0 889
4CXA A X-ray 3.15 2 B 1.0

Mutations

Showing 4 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
530 P A Polymorphism
912 R H Unclassified A colorectal adenocarcinoma sample
1189 L Q Polymorphism
1275 P L Polymorphism