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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 11 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
1224 SER PRIDE yes
1311 SER PRIDE yes
1377 SER PRIDE
1380 THR PRIDE
2306 SER PRIDE yes
2922 SER PRIDE
2927 THR PRIDE
3049 THR PRIDE yes
3168 THR PRIDE yes
3637 TYR PRIDE
3639 THR PRIDE

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 13 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
1224 1222 1227 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
1311 1297 1313 15 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1377 1371 1383 7 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 6 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD000612 9 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD001333 4 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
1380 1371 1383 10 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 6 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
PXD000612 9 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001333 4 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
1380 1377 1387 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001550 1 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture
1380 1377 1383 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
2306 2303 2309 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
2922 2917 2928 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 4 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
2927 2917 2928 11 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 4 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
3049 3041 3053 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
3168 3158 3170 11 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
3637 3631 3649 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD003198 1 Characterisation of pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling Homo sapiens (Human) PARTIAL 2016-06-09 pancreatic cell line
3639 3631 3649 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD003198 1 Characterisation of pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling Homo sapiens (Human) PARTIAL 2016-06-09 pancreatic cell line

Structures

Showing 1 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
4RH7 A X-ray 3.4100000858306885 2 [ADP]A:4405 0.19930838 1311, 1377, 1380, 2306, 2922, 2927, 3049, 3168, 3637, 3639
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
1311 1311 SER H 1.0 64.81002807617188 0.0
1377 1377 SER H 1.0 61.39830780029297 0.0
1380 1380 THR H 0.42 66.39684295654297 0.0
1521 1521 THR H 0.86 66.20780944824219 0.0
2259 2259 THR C 0.75 103.77510833740234 0.0
2306 2306 SER H 1.0 67.73374938964844 0.0
2922 2922 SER H 1.0 58.66842269897461 0.0
2927 2927 THR H 0.87 64.53234100341797 0.0
3049 3049 THR C 1.0 75.821533203125 0.0
3168 3168 THR H 1.0 61.219276428222656 0.0
3264 3264 SER H 1.0 3.0738863945007324 0.0
3446 3446 THR H 1.0 95.87116241455078 0.0
3637 3637 TYR H 1.0 25.815540313720703 0.0
3639 3639 THR H 0.65 91.94700622558594 0.0

Mutations

Showing 47 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
209 F I Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
302 T P Polymorphism
304 Q L Polymorphism
330 R C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
338 R G Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
341 H Y Polymorphism
430 R C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
456 R Q Polymorphism
495 K R Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
587 R C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
789 R K Polymorphism
871 L P Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1221 R K Polymorphism
1228 L I Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1240 I T Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1288 T A Polymorphism
1379 M V Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1413 K R Polymorphism
1423 R C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1442 G D Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1537 Q R Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1987 T A Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
1991 M K Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2205 R H Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2227 M V Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2304 A T Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2362 N S Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2461 G V Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2481 R Q Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2496 P S Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2532 R W Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2555 V M Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2573 Y C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2640 I T Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2662 R Q Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2819 I M Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
2871 R Q Polymorphism
3015 D G Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
3381 P L Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
3680 A V Polymorphism
3762 L V Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
3806 R C Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
3847 W G Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]
3909 G D Disease
3976 S N Polymorphism
4139 Q P Polymorphism
4232 L R Disease Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]