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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 14 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
13 SER PRIDE yes
17 SER PRIDE
44 SER PRIDE
93 SER PRIDE yes
207 SER PRIDE yes
212 TYR PRIDE yes
242 THR PRIDE yes
245 SER UP, PRIDE Combined yes
268 SER UP, PRIDE Combined yes
302 SER PRIDE yes
303 THR PRIDE yes
305 THR PRIDE
306 THR UP, PRIDE Combined
597 SER UP, PRIDE Combined yes

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 21 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
13 11 23 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
17 11 23 7 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 1 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD001546 1 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD001550 3 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture
17 12 47 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 2 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
44 12 47 33 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 2 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
93 91 115 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
207 207 221 1 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 7 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 4 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
212 207 221 6 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
242 235 248 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 1 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
242 237 248 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
245 235 248 11 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 1 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
245 237 248 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
268 255 279 14 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
268 266 279 3 11
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004252 1 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD001060 8 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD000612 108 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002436 2 Monitoring cellular phosphorylation signaling pathways into chromatin and down to the gene level Homo sapiens (Human) COMPLETE 2015-11-09 HeLa cell -
PXD004415 3 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte -
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
PXD002286 13 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 3 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 3 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
302 298 309 5 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD005366 1 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
303 298 309 6 5
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 19 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD005366 5 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
303 298 310 6 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 5 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD001333 2 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
305 298 310 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
306 298 310 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
306 298 309 9 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD001333 3 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
597 594 606 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
597 595 606 3 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 7 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 14 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -

Structures

Showing 1 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
3VFD A X-ray 3.299999952316284 Monomer [SO4]A:701 0.1
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
597 598 SER C 0.84 38.34841537475586 0.0

Mutations

Showing 83 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
44 S L Polymorphism
45 P Q Polymorphism
95 A T Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
97 P T Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
162 V I Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
195 L V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
201 V D Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
229 S G Polymorphism
293 P L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
309 R H Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
314 L S Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
328 I K Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
344 I K Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
347 Q K Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
356 E K Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
360 L V Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
361 P L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
362 S C Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
363 L P Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
364 R T Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
365 P S Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
366 E K Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
368 F V Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
370 G R Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
372 R T Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
377 G E Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
378 L Q Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
380 L H Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
381 F C Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
382 G R Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
386 N Y Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
388 K R Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
390 M V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
391 L P Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
399 S L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
406 I V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
407 S I Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
409 A T Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
410 S R Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
413 S L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
418 E A Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
422 L F Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
423 V L Unclassified A breast cancer sample
424 R G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
426 L V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
435 P L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
436 S F Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
441 D V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
445 S N Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
448 C Y Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
450 R S Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
454 E K Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
458 S R Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
459 R G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
460 R C Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
461 L P Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
463 T A Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
464 E A Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
470 D Y Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
482 V L Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
485 A V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
489 P L Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
492 L F Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
493 D G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
498 R G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
499 R H Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
503 R W Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
512 E D Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
514 R G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
534 L P Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
550 T I Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
551 A Y Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
555 D G Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
556 A V Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
559 G D Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
562 R P Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
579 N H Unclassified Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
580 I T Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
584 D H Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
595 S R Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
607 W C Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
614 T I Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]
615 T I Disease Spastic paraplegia 4, autosomal dominant (SPG4) [MIM:182601]