Welcome to Scop3P

Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

  • Zoom in and zoom out (both with mouse and buttons on the right top corner) to see modificationson the protein
  • Slide the chart to see other modifications (both with mouse and buttons on the right topcorner)
  • Hover on the modification to see more information and position on the structure.
PDB 
 AlphaFold
Phospho-sites

Showing 3 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
47 SER UP, PRIDE Experimental yes
246 SER PRIDE yes
688 SER UP, PRIDE Combined yes

3D structure is not available

Display Settings

Hover over to see the values, zoom (in/out) or drag by using the mouse pointer.

Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 4 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
47 47 66 1 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 2 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
PXD000836 1 HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies Homo sapiens (Human) PARTIAL 2014-05-22 lung -
246 238 248 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
688 681 692 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
688 683 692 6 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD001374 1 Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling Homo sapiens (Human) PARTIAL 2015-08-24 HeLa cell -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -

Structures

Showing 28 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
4NMX B X-ray 1.850000023841858 3 A 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 42.074913024902344 0.0
249 249 SER E 0.89 5.556371688842773 0.0
2QTW B X-ray 1.899999976158142 2 A 0.75261647 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 42.03335189819336 0.0
249 249 SER E 0.89 5.005101680755615 0.0
2P4E A X-ray 1.9800000190734863 2 P 0.33228403 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 45.647708892822266 0.0
249 249 SER E 0.89 5.693268775939941 0.0
5VLK A X-ray 2.200000047683716 3 [CA]A:501 0.56252146 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 42.16658401489258 0.0
249 249 SER E 0.89 6.567890167236328 0.0
2W2N A X-ray 2.299999952316284 2 P 0.6709556 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 29.81295394897461 0.0
249 249 SER E 0.89 6.706233024597168 0.0
5OCA B X-ray 2.299999952316284 4 A 0.39965874 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER C 0.57 31.970834732055664 0.0
249 249 SER E 0.89 4.866611480712891 0.0
3H42 B X-ray 2.299999952316284 4 A 0.6812808 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 29.269668579101562 0.0
249 249 SER E 0.89 7.695741653442383 0.0
2PMW B X-ray 2.299999952316284 2 A 0.48733145 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 49.3991584777832 0.0
249 249 SER E 0.89 6.133778095245361 0.0
2W2Q A X-ray 2.3299999237060547 3 P 0.6618686 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER C 0.57 27.722579956054688 0.0
249 249 SER E 0.89 5.818288803100586 0.0
5VLL A X-ray 2.369999885559082 3 [CA]A:501 0.57167727 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 46.64857482910156 0.0
249 249 SER E 0.89 6.353958606719971 0.0
5VLA A X-ray 2.4000000953674316 2 Z 0.5076171 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 41.56758499145508 0.0
249 249 SER E 0.89 5.595810890197754 0.0
2W2M A X-ray 2.4000000953674316 2 P 0.6863744 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 21.693220138549805 0.0
249 249 SER E 0.89 6.283455848693848 0.0
3BPS A X-ray 2.4100000858306885 2 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 24.88140106201172 0.0
249 249 SER E 0.89 2.2649013996124268 0.0
4NE9 A X-ray 2.5999999046325684 3 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 28.259700775146484 0.0
249 249 SER E 0.89 6.2315144538879395 0.0
2W2O A X-ray 2.619999885559082 2 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 38.725677490234375 0.0
249 249 SER E 0.89 4.907903671264648 0.0
2W2P A X-ray 2.619999885559082 3 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 30.187299728393555 0.0
249 249 SER E 0.89 6.977651119232178 0.0
4OV6 B X-ray 2.690000057220459 3 A 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 40.054840087890625 0.0
249 249 SER E 0.89 6.456851482391357 0.0
3GCW A X-ray 2.700000047683716 2 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 24.460086822509766 0.0
249 249 SER E 0.89 2.6195240020751953 0.0
3SQO A X-ray 2.700000047683716 2 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 36.10083770751953 0.0
249 249 SER E 0.89 4.620554447174072 0.0
3GCX A X-ray 2.700000047683716 2 P 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 23.224790573120117 0.0
249 249 SER E 0.89 2.0638887882232666 0.0
2XTJ A X-ray 2.700000047683716 4 P 0.67633104 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER C 0.57 24.591384887695312 0.0
249 249 SER E 0.89 5.250452041625977 0.0
5VLH A X-ray 2.859999895095825 3 [CA]A:501 0.5507263 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 41.7872428894043 0.0
249 249 SER E 0.89 5.616788387298584 0.0
5VLP A X-ray 2.9000000953674316 4 Z 0.37507385 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 21.58709716796875 0.0
249 249 SER E 0.89 5.543183326721191 0.0
4K8R B X-ray 3.2200000286102295 6 A 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 30.635427474975586 0.0
249 249 SER E 0.89 7.228617191314697 0.0
3P5B A X-ray 3.299999952316284 2 P 0.668046 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 12.126529693603516 0.0
249 249 SER E 0.89 4.927953243255615 0.0
5VL7 B X-ray 3.5 4 A 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 30.946168899536133 0.0
249 249 SER E 0.89 4.340176105499268 0.0
3P5C A X-ray 4.199999809265137 2 P 0.6683522 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 12.193822860717773 0.0
249 249 SER E 0.89 4.970694065093994 0.0
3M0C B X-ray 7.010000228881836 2 A 1.0 246
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
246 246 SER E 0.57 42.456871032714844 0.0
249 249 SER E 0.89 4.937664031982422 0.0

Mutations

Showing 38 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
46 R L Polymorphism
53 A V Polymorphism
57 E K Polymorphism
77 T I Polymorphism
93 R C Polymorphism
106 G R Polymorphism
114 V A Polymorphism
127 S R Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
129 D G Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
157 N K Polymorphism
174 P S Polymorphism
215 R H Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
216 F L Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
218 R S Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
219 Q E Polymorphism
237 R W Polymorphism
239 A D Polymorphism
253 L F Polymorphism
357 R H Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
374 D Y Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
391 H N Polymorphism
394 G S Unclassified
417 H Q Polymorphism
425 N S Polymorphism
443 A T Polymorphism
452 G D Polymorphism
469 R W Polymorphism
474 V I Polymorphism
482 E G Polymorphism
496 R W Disease Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3) [MIM:603776]
515 F L Polymorphism
522 A T Polymorphism
553 H R Polymorphism
554 Q E Polymorphism
616 P L Polymorphism
619 Q P Polymorphism
668 S R Polymorphism
670 G E Polymorphism