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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 20 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
318 THR PRIDE yes
380 THR PRIDE yes
479 SER PRIDE yes
773 THR PRIDE yes
973 TYR PRIDE yes
1000 THR PRIDE yes
1098 SER PRIDE
1101 THR PRIDE
1102 SER PRIDE
1105 SER UP, PRIDE Combined
1108 SER UP, PRIDE Similarity
1112 THR PRIDE yes
1180 THR PRIDE yes
1185 TYR PRIDE yes
1189 THR PRIDE yes
1287 TYR PRIDE yes
1328 SER UP, PRIDE Combined yes
1333 SER PRIDE yes
1336 SER PRIDE yes
1341 SER PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 20 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
318 311 323 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000218 1 System-level analysis of cancer and stomal cell specific proteomes reveals extensive reprogramming of phosphorylation networks by tumor microenvironment Homo sapiens (Human),Mus musculus (Mouse) COMPLETE 2014-04-01 Epithelial cell, colon
380 350 385 31 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
479 476 486 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 2 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
773 771 782 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
973 968 977 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1000 997 1005 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
1098 1094 1120 5 5
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 3 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001546 1 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD001550 1 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD000680 2 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
1101 1094 1120 8 6
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004252 1 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 6 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD001550 7 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD004452 2 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
1102 1094 1120 9 6
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 8 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD002286 2 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 3 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
PXD001550 5 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD004452 5 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
1105 1094 1120 12 9
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004252 2 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture
PXD000612 30 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001546 9 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD003531 2 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD002286 11 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 13 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 7 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD001550 29 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
1108 1094 1120 15 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001546 4 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture
PXD002286 7 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD001550 8 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
1112 1094 1120 19 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001550 1 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture
1180 1173 1186 8 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 2 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
1185 1173 1194 13 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1189 1187 1194 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD002286 28 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
PXD006482 3 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
1287 1285 1293 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 7 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1328 1319 1330 10 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 8 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD003531 5 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004452 3 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
1333 1331 1344 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
1336 1336 1343 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
1341 1336 1344 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell

Structures

Showing 19 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
3V8S A X-ray 2.2899999618530273 2 B 0.9214218 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
318 318 THR C 1.0 31.313600540161133 0.0
361 361 SER C 0.92 56.64529800415039 0.0
365 365 THR C 1.0 26.051593780517578 0.0
366 366 SER C 1.0 83.25534057617188 0.0
380 380 THR C 1.0 39.61756896972656 0.0
1S1C X X-ray 2.5999999046325684 3 Y 1.0 973, 1000
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
973 973 TYR H 0.78 152.5509796142578 78.44197082519531
1000 1000 THR H 0.86 55.700172424316406 0.0
2ETR A X-ray 2.5999999046325684 2 B 0.7337914 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 99.2923355102539 0.16792519390583038
318 318 THR C 1.0 33.449554443359375 0.0
361 361 SER C 0.92 54.25851058959961 0.0
365 365 THR C 1.0 11.416312217712402 0.0
366 366 SER C 1.0 88.5497817993164 0.0
380 380 THR C 1.0 41.697452545166016 0.0
405 405 TYR C 0.46 211.40391540527344 12.09095573425293
3TV7 A X-ray 2.75 2 B 0.8229452 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
318 318 THR C 1.0 36.7784423828125 0.0
361 361 SER C 0.92 51.6057014465332 0.0
365 365 THR C 1.0 24.1803035736084 0.0
366 366 SER C 1.0 78.2490234375 0.0
380 380 THR C 1.0 93.54265594482422 0.0
5HVU A X-ray 2.799999952316284 4 B 0.9788096 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 100.36123657226562 6.42302131652832
318 318 THR C 1.0 29.370145797729492 0.0
361 361 SER C 0.92 57.047542572021484 0.0
365 365 THR C 1.0 19.712203979492188 0.0
366 366 SER C 1.0 89.94116973876953 0.0
380 380 THR C 1.0 89.54119110107422 0.0
405 405 TYR C 0.46 206.94857788085938 12.390331268310547
4W7P A X-ray 2.799999952316284 2 B 0.9151631 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 109.21978759765625 5.959110260009766
318 318 THR C 1.0 40.35743713378906 0.0
361 361 SER C 0.92 50.49755859375 0.0
365 365 THR C 1.0 17.85103988647461 0.0
366 366 SER C 1.0 84.77775573730469 0.0
380 380 THR C 1.0 52.353126525878906 0.0
405 405 TYR C 0.46 174.111572265625 0.0
5KKT A X-ray 2.799999952316284 4 B 0.8887044 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 96.03380584716797 6.992988586425781
318 318 THR C 1.0 26.449569702148438 0.0
361 361 SER C 0.92 58.54664611816406 0.0
365 365 THR C 1.0 18.04561996459961 0.0
366 366 SER C 1.0 90.14571380615234 0.0
380 380 THR C 1.0 55.273685455322266 0.0
405 405 TYR C 0.46 200.93862915039062 13.385822296142578
3TWJ A X-ray 2.9000000953674316 4 B 0.8939502 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
318 318 THR C 1.0 47.32835388183594 0.0
361 361 SER C 0.92 46.72409439086914 0.0
365 365 THR C 1.0 24.4073486328125 0.0
366 366 SER C 1.0 85.96792602539062 0.0
380 380 THR C 1.0 103.83917999267578 0.0
5BML A X-ray 2.950000047683716 2 B 0.91523767 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 96.15809631347656 3.5160226821899414
318 318 THR C 1.0 28.742406845092773 0.0
361 361 SER C 0.92 58.641231536865234 0.0
365 365 THR C 1.0 18.392885208129883 0.0
366 366 SER C 1.0 91.83758544921875 0.0
380 380 THR C 1.0 79.57420349121094 0.0
405 405 TYR C 0.46 213.02268981933594 11.107542037963867
2ETK A X-ray 2.9600000381469727 2 B 1.0 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 95.24527740478516 4.810300350189209
318 318 THR C 1.0 35.2242546081543 0.0
361 361 SER C 0.92 55.90731430053711 0.0
365 365 THR C 1.0 14.17510986328125 0.0
366 366 SER C 1.0 82.77680206298828 0.0
380 380 THR C 1.0 46.43209457397461 0.0
405 405 TYR C 0.46 209.42889404296875 12.037130355834961
3NCZ A X-ray 3.0 2 B 0.7834942 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 56.563270568847656 18.284011840820312
318 318 THR C 1.0 40.32677459716797 0.0
361 361 SER C 0.92 54.92158889770508 0.0
365 365 THR H 1.0 25.091182708740234 0.0
366 366 SER H 1.0 71.01705932617188 0.0
380 380 THR C 1.0 94.59403228759766 0.0
4YVC A X-ray 3.200000047683716 2 B 0.94094706 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 101.98969268798828 3.3469884395599365
318 318 THR C 1.0 29.226484298706055 0.0
361 361 SER C 0.92 51.391170501708984 0.0
365 365 THR C 1.0 19.529634475708008 0.0
366 366 SER C 1.0 87.5273666381836 0.0
380 380 THR C 1.0 45.17489242553711 0.0
405 405 TYR C 0.46 210.760498046875 11.776541709899902
2ESM A X-ray 3.200000047683716 2 B 1.0 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 92.24068450927734 0.5025569796562195
318 318 THR C 1.0 32.07908630371094 0.0
361 361 SER C 0.92 54.6699104309082 0.0
365 365 THR C 1.0 13.138524055480957 0.0
366 366 SER C 1.0 86.42415618896484 0.0
380 380 THR C 1.0 45.04887008666992 0.0
405 405 TYR C 0.46 206.21241760253906 10.547127723693848
5UZJ A X-ray 3.299999952316284 2 B 1.0 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 93.44357299804688 3.0131046772003174
318 318 THR C 1.0 28.595977783203125 0.0
361 361 SER C 0.92 55.55662536621094 0.0
365 365 THR C 1.0 20.314298629760742 0.0
366 366 SER C 1.0 86.42820739746094 0.0
380 380 THR C 1.0 73.36631774902344 0.0
405 405 TYR C 0.46 215.1305694580078 9.449070930480957
3NDM A X-ray 3.299999952316284 4 B 0.8132099 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 48.63747024536133 3.823821544647217
318 318 THR C 1.0 33.98051452636719 0.0
361 361 SER C 0.92 59.64673614501953 0.0
365 365 THR H 1.0 22.924428939819336 0.0
366 366 SER H 1.0 77.45948028564453 0.0
380 380 THR C 1.0 76.94549560546875 0.0
3D9V A X-ray 3.299999952316284 2 B 1.0 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 98.00790405273438 2.977168321609497
318 318 THR C 1.0 33.34920120239258 0.0
361 361 SER C 0.92 58.497920989990234 0.0
365 365 THR C 1.0 15.176810264587402 0.0
366 366 SER C 1.0 84.58432006835938 0.0
380 380 THR C 1.0 49.91933059692383 0.0
405 405 TYR C 0.46 205.0232391357422 11.385313034057617
5KKS A X-ray 3.299999952316284 2 B 0.824586 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 108.81998443603516 0.0
318 318 THR C 1.0 29.31678581237793 0.0
361 361 SER C 0.92 60.071441650390625 0.0
365 365 THR C 1.0 25.889341354370117 0.0
366 366 SER C 1.0 87.25247955322266 0.0
380 380 THR C 1.0 85.76986694335938 0.0
405 405 TYR C 0.46 195.40977478027344 11.299812316894531
4YVE A X-ray 3.4000000953674316 2 B 1.0 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 87.58209991455078 1.8414890766143799
318 318 THR C 1.0 31.499052047729492 0.0
361 361 SER C 0.92 54.852237701416016 0.0
365 365 THR C 1.0 24.74355697631836 0.0
366 366 SER C 1.0 90.98743438720703 0.0
380 380 THR C 1.0 55.40425109863281 0.0
405 405 TYR C 0.46 193.61502075195312 12.614627838134766
2V55 A X-ray 3.700000047683716 4 A 0.5285955 318, 380
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
6 6 SER C 0.67 122.91260528564453 8.014311790466309
318 318 THR C 1.0 26.36361312866211 0.0
361 361 SER C 0.92 66.26766204833984 0.0
365 365 THR C 1.0 18.40533447265625 0.0
366 366 SER C 1.0 78.4428482055664 0.0
380 380 THR C 1.0 67.76435852050781 0.0

Mutations

Showing 7 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
108 S N Polymorphism
773 T S Polymorphism
1112 T P Polymorphism
1193 P S Unclassified A lung neuroendocrine carcinoma sample
1217 Q E Polymorphism
1262 R Q Polymorphism
1264 C R Polymorphism