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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 6 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
238 TYR PRIDE yes
479 SER PRIDE yes
570 TYR PRIDE yes
637 SER PRIDE yes
921 SER UP, PRIDE Combined
928 SER PRIDE

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 7 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
238 236 243 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 3 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
479 472 490 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
570 568 579 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
637 632 638 6 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD003531 2 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
921 913 929 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
921 919 929 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD005366 1 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
928 913 929 16 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell

Structures

Showing 9 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
3THX A X-ray 2.700000047683716 4 B 0.7839141 238, 479, 570, 637, 921, 928
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR H 0.69 89.13941955566406 0.0
479 479 SER H 0.79 47.36018753051758 0.0
495 495 THR H 0.78 15.867210388183594 0.0
570 570 TYR H 1.0 17.493972778320312 0.0
637 637 SER E 0.85 1.0230216979980469 0.0
921 921 SER H 0.44 73.92027282714844 0.0
928 928 SER H 0.76 80.5987777709961 0.0
3THY A X-ray 2.890000104904175 4 B 0.86616945 238, 479, 570, 637, 921, 928
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR H 0.69 82.38715362548828 0.0
479 479 SER H 0.79 45.48648452758789 0.0
495 495 THR H 0.78 12.97186279296875 0.0
570 570 TYR H 1.0 13.989696502685547 0.0
637 637 SER E 0.85 0.7360371947288513 0.0
921 921 SER H 0.44 73.4770736694336 0.0
928 928 SER H 0.76 81.03726959228516 0.0
3THW A X-ray 3.0899999141693115 3 B 0.8663814 238, 479, 570, 637, 921, 928
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR H 0.69 81.92347717285156 0.0
479 479 SER H 0.79 55.1854248046875 0.0
495 495 THR H 0.78 19.62282371520996 0.0
570 570 TYR H 1.0 26.783143997192383 0.0
637 637 SER E 0.85 0.0 0.0
921 921 SER H 0.44 65.79515838623047 0.0
928 928 SER H 0.76 85.49422454833984 0.0
3THZ A X-ray 4.300000190734863 4 B 0.8672451 238, 479, 570, 637, 921, 928
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR H 0.69 75.85015869140625 0.0
479 479 SER H 0.79 55.96106719970703 0.0
495 495 THR H 0.78 18.997045516967773 0.0
570 570 TYR H 1.0 23.976552963256836 0.0
637 637 SER E 0.85 0.0 0.0
921 921 SER H 0.44 64.02871704101562 0.0
928 928 SER H 0.76 85.71253967285156 0.0
2O8B A X-ray 2.75 4 B 0.5694743 238, 479, 570, 637
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR H 0.69 103.15869140625 0.0
479 479 SER H 0.79 36.494388580322266 0.0
495 495 THR H 0.78 12.940363883972168 0.0
570 570 TYR H 1.0 34.987361907958984 0.0
637 637 SER E 0.85 0.0 0.0
2O8D A X-ray 3.0 4 B 0.57676136 238, 479, 570, 637
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR C 0.69 110.21235656738281 0.0
479 479 SER H 0.79 36.30216598510742 0.0
495 495 THR H 0.78 22.83792495727539 0.0
570 570 TYR H 1.0 36.40664291381836 0.0
637 637 SER E 0.85 0.0 0.0
2O8F A X-ray 3.25 4 B 0.73894596 238, 479, 570, 637
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR C 0.69 131.05325317382812 0.0
479 479 SER H 0.79 29.06053352355957 0.0
495 495 THR H 0.78 9.544451713562012 0.0
570 570 TYR H 1.0 26.205184936523438 0.0
637 637 SER E 0.85 0.0 0.0
2O8E A X-ray 3.299999952316284 4 B 0.7270561 238, 479, 570, 637
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR C 0.69 129.68251037597656 0.0
479 479 SER H 0.79 30.764745712280273 0.0
495 495 THR H 0.78 23.986587524414062 0.0
570 570 TYR H 1.0 32.102996826171875 0.0
637 637 SER E 0.85 0.0 0.0
2O8C A X-ray 3.369999885559082 4 B 0.56989974 238, 479, 570, 637
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
238 238 TYR C 0.69 123.3836441040039 0.0
479 479 SER H 0.79 37.11343002319336 0.0
495 495 THR H 0.78 19.726070404052734 0.0
570 570 TYR H 1.0 37.22079849243164 0.0
637 637 SER E 0.85 0.0 0.0

Mutations

Showing 123 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
2 A T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
5 P Q Polymorphism
8 T M Polymorphism
13 S I Unclassified Colorectal cancer (CRC) [MIM:114500]
17 V F Unclassified Gastric cancer
33 T P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
40 G S Unclassified Colorectal cancer (CRC) [MIM:114500]
43 Y C Polymorphism
44 T M Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
45 A V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
46 H Q Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
55 R G Polymorphism
93 L F Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
96 R H Polymorphism
98 Y C Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
102 V I Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
106 R K Polymorphism
110 K T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
127 N S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
139 N S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
145 I M Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
161 V D Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
162 G R Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
163 V D Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
164 G R Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
165 Y D Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
167 D H Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
169 I V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
173 L P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
175 L P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
177 E H Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
187 L P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
198 E G Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
199 C R Unclassified Glioma
203 G R Unclassified Colorectal cancer (CRC) [MIM:114500]
205 E Q Polymorphism
216 I V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
246 K Q Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
272 A V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
283 D Y Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
305 A T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
322 G D Polymorphism
323 S C Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
328 A P Polymorphism
331 N D Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
333 C Y Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
335 T I Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
336 P S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
342 V I Unclassified Colorectal cancer (CRC) [MIM:114500]
349 P L Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
359 R S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
367 V I Polymorphism
385 P L Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
390 L F Unclassified Colorectal cancer (CRC) [MIM:114500]
393 K M Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
419 Q K Unclassified Colorectal cancer (CRC) [MIM:114500]
470 V E Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
487 D E Polymorphism
492 M V Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
506 D Y Disease Colorectal cancer (CRC) [MIM:114500]
519 F L Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
524 R P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
534 R P Polymorphism
552 T P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
554 S R Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
562 E V Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
564 T A Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
583 N S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
596 N S Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
600 A V Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
603 D N Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
610 H N Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
619 Y C Unclassified Colorectal cancer (CRC) [MIM:114500]
622 P L Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
629 Q R Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
636 A P Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
638 R G Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
639 H Y Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
641 C G Polymorphism
645 Q E Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
647 E K Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
656 Y H Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
660 D G Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
669 G R Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
670 P L Polymorphism
671 N Y Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
674 G S Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
675 K A Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
679 I T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
688 M I Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
692 G R Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
696 P L Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
697 C R Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
714 A V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
722 V I Polymorphism
723 S F Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
729 M V Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
732 T I Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
748 D Y Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
749 E K Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
759 G E Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
770 I V Polymorphism
779 M I Polymorphism
805 L V Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
807 T S Polymorphism
813 M V Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
824 Q E Unclassified Gastric cancer
834 A T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
835 N H Polymorphism
839 H Q Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
843 C G Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
845 K E Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
853 E A Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
860 S L Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
868 P A Unclassified Gastric cancer
870 A G Unclassified Gastric cancer
873 C G Unclassified Gastric cancer
886 E G Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
905 T R Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
909 K I Polymorphism
911 L R Polymorphism
923 V E Unclassified Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]
931 K T Disease Hereditary non-polyposis colorectal cancer 1 (HNPCC1) [MIM:120435]