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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

M3K7_HUMAN : Mitogen-activated protein kinase kinase kinase 7

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PDB 
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Phospho-sites

Showing 16 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
184 THR UP Experimental
187 THR UP Experimental
192 SER UP Experimental
331 SER PRIDE yes
333 THR PRIDE yes
344 THR PRIDE yes
367 SER UP, PRIDE Combined yes
375 SER PRIDE yes
389 SER UP, PRIDE Combined yes
415 THR PRIDE yes
417 SER PRIDE yes
439 SER UP, PRIDE Combined
444 THR PRIDE yes
455 SER UP, PRIDE Combined
459 SER PRIDE yes
472 SER PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 19 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
SDTNMEQVPATNDTIK 331 331 346 1 1
SDTNMEQVPATNDTIK 333 331 346 3 3
SDTNMEQVPATNDTIK 344 331 346 14 2
QQSESGRLSLGASR 367 359 372 9 2
LSLGASR 367 366 372 2 2
GSSVESLPPTSEGKR 375 373 387 3 1
GSSVESLPPTSEGK 375 373 386 3 3
RMSADMSEIEAR 389 387 398 3 9
MSADMSEIEAR 389 388 398 2 6
KTASFGNILDVPEIVISGNGQPR 415 414 436 2 2
TASFGNILDVPEIVISGNGQPR 415 415 436 1 3
TASFGNILDVPEIVISGNGQPR 417 415 436 3 3
RRSIQDLTVTGTEPGQVSSR 439 437 456 3 10
SIQDLTVTGTEPGQVSSR 439 439 456 1 13
SIQDLTVTGTEPGQVSSR 444 439 456 6 2
RRSIQDLTVTGTEPGQVSSR 455 437 456 19 2
SIQDLTVTGTEPGQVSSR 455 439 456 17 2
SSSPSVR 459 457 463 3 1
MITTSGPTSEKPTR 472 464 477 9 1

Structures

Showing 20 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
5GJF A X-ray 2.89 4 A 0.5187105 184, 187, 192
2EVA A X-ray 2.0 Monomer A 0.0 192
5JGA A X-ray 2.0 Monomer [6KC]A:601 0.1 192
5V5N A X-ray 2.01 Monomer [EDH]A:501 0.1 192
5E7R A X-ray 2.11 Monomer [5KW]A:601 0.1 192
4GS6 A X-ray 2.2 4 [1FM]A:611 1.0 192
5JH6 A X-ray 2.37 Monomer [T92]A:601 0.1 192
5JK3 A X-ray 2.37 Monomer [6L4]A:601 0.1 192
5J7S A X-ray 2.37 Monomer [6H3]A:601 0.1 192
4O91 A X-ray 2.39 4 [NG2]A:601 0.39098796 192
5J8I A X-ray 2.4 Monomer [6H4]A:601 0.1 192
2YIY A X-ray 2.49 4 [YIY]A:4000 0.53975934 192
4L52 A X-ray 2.54 Monomer [1UL]A:501 0.1 192
4L53 A X-ray 2.55 Monomer [1UO]A:501 0.1576883 192
5GJG A X-ray 2.61 4 [6V5]A:601 0.5816752 192
4L3P A X-ray 2.68 Monomer A 0.0 192
5J9L A X-ray 2.75 Monomer [6HF]A:501 0.1 192
5GJD A X-ray 2.79 Monomer [6V3]A:601 0.1 192
5JGB A X-ray 2.8 Monomer [6JV]A:601 0.1 192
5JGD A X-ray 3.1 Monomer [6KD]A:601 0.1 192

Mutations

Showing 7 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
70 E Q Disease Frontometaphyseal dysplasia 2 (FMD2) [MIM:617137]
100 V E Disease Frontometaphyseal dysplasia 2 (FMD2) [MIM:617137]
110 G C Disease Cardiospondylocarpofacial syndrome (CSCF) [MIM:157800]
168 G R Disease Frontometaphyseal dysplasia 2 (FMD2) [MIM:617137]
241 W R Disease Cardiospondylocarpofacial syndrome (CSCF) [MIM:157800]
410 R Q Unclassified
512 P L Disease Frontometaphyseal dysplasia 2 (FMD2) [MIM:617137]