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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 11 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
14 SER PRIDE yes
20 SER PRIDE yes
27 SER UP, PRIDE Similarity yes
51 SER PRIDE yes
130 SER UP Similarity
322 THR UP Similarity
450 SER UP Combined
466 SER UP Combined
544 SER UP, PRIDE Combined yes
583 TYR PRIDE yes
610 SER PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 8 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
14 2 15 13 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 3 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
20 20 33 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
27 19 33 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 1 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
51 19 54 33 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD005366 1 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
544 542 551 3 16
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 10 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
PXD004252 12 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD000474 5 Simulated phosphopeptide spectral library for confident site localization Homo sapiens (Human) PARTIAL 2015-03-17 HeLa cell -
PXD004940 9 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD003531 47 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD006482 3 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD002286 235 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 70 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD002394 1 Proteomic and phosphoproteomic analysis of cisplatin resistance in patient derived serous ovarian cancer Homo sapiens (Human) PARTIAL 2017-05-02 cell suspension culture -
PXD001550 2 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD004452 16 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD000680 40 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
PXD000836 1 HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies Homo sapiens (Human) PARTIAL 2014-05-22 lung -
PXD000612 109 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001546 5 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
544 542 563 3 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001060 1 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD004415 27 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte -
PXD001550 9 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture
PXD000680 8 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
583 583 590 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
610 591 616 20 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD000612 5 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture

Structures

Showing 3 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
6CAJ A EM 2.799999952316284 Monomer D 0.0 51, 130, 322, 450, 466
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
51 51 SER C 0.78 17.485506057739258 0.0
130 130 SER C 1.0 19.86095428466797 0.0
322 322 THR C 0.97 5.316522598266602 0.0
450 450 SER C 1.0 1.0010493993759155 0.0
466 466 SER C 0.91 136.20693969726562 0.0
6EZO I EM 4.099999904632568 Monomer C 0.0 130, 322, 450
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
130 130 SER C 1.0 79.79234313964844 0.0
322 322 THR C 0.97 16.63317108154297 0.0
450 450 SER C 1.0 131.56602478027344 0.0
3JUI A X-ray 2.0 Monomer [GOL]A:1 0.1 583, 610
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
583 583 TYR H 0.96 154.14410400390625 0.0
610 610 SER C 0.52 81.78974914550781 0.0

Mutations

Showing 23 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
62 D V Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
68 L S Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
73 V G Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
74 A T Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
91 T A Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
106 L F Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
113 R C Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
195 R C Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
200 N T Polymorphism
269 R G Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
270 D H Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
299 R H Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
310 C F Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
315 R H Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
335 C S Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
339 R P Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
376 N D Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
386 G V Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
430 V A Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
447 S L Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
587 I V Polymorphism
628 W R Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]
650 E K Disease Leukodystrophy with vanishing white matter (VWM) [MIM:603896]