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PTPS_HUMAN : 6-pyruvoyl tetrahydrobiopterin synthase

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PDB 
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Phospho-sites

Showing 6 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
2 SER PRIDE
3 THR PRIDE
19 SER UP, PRIDE Combined yes
28 SER UP Similarity
128 TYR UP, PRIDE Combined yes
133 TYR PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 6 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
MSTEGGGRRCQAQVSR 2 1 16 2 1
MSTEGGGRRCQAQVSR 3 1 16 3 1
RISFSASHR 19 17 25 3 10
ISFSASHR 19 18 25 2 1
VLPVGVLYK 128 121 129 8 1
VYETDNNIVVYK 133 132 143 2 1

Structures

Showing 1 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
3I2B A X-ray 2.3 6 [NI]A:146 0.63772446 19, 28, 128, 133

Mutations

Showing 21 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
16 R C Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
25 R Q Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
26 L F Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
35 E G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
36 N K Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
47 N D Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
52 N S Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
56 V M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
67 T M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
70 V D Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
87 P L Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
96 D N Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
97 V M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
99 Y C Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
100 F V Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
106 T M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
114 I V Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
116 D G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
124 V L Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
129 K E Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
136 D G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]