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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 9 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
291 THR PRIDE yes
606 TYR PRIDE yes
696 SER UP, PRIDE Combined yes
699 SER PRIDE yes
806 TYR UP Experimental
809 TYR UP Experimental
900 TYR UP Experimental
905 TYR UP Experimental
981 TYR UP Experimental

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 4 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
291 289 297 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
606 601 617 6 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004252 1 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture
PXD000612 5 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
696 694 710 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 9 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
699 694 710 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI 
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon

Structures

Showing 15 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
2IVS A X-ray 2.0 2 B 0.73572105 806, 809, 900, 905, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 56.86696243286133 0.0
809 809 TYR C 0.97 61.009681701660156 0.0
900 900 TYR C 0.96 66.43339538574219 0.0
905 905 TYR E 0.96 53.62587356567383 0.0
981 981 TYR H 1.0 40.62303924560547 0.0
4CKJ A X-ray 1.65 2 A 0.73268116 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 58.456966400146484 0.0
809 809 TYR C 0.97 75.71170806884766 0.0
900 900 TYR C 0.96 157.248291015625 0.0
981 981 TYR H 1.0 37.89502716064453 0.0
2X2L A X-ray 2.0 2 A 0.5444291 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 61.125850677490234 0.0
809 809 TYR C 0.97 68.88103485107422 0.0
900 900 TYR - 0.96 58.59127426147461 0.0
981 981 TYR H 1.0 39.80398941040039 0.0
2IVV A X-ray 2.25 2 A 0.75417155 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 59.239532470703125 0.0
809 809 TYR C 0.97 85.67840576171875 0.0
900 900 TYR C 0.96 86.7756576538086 0.0
981 981 TYR H 1.0 39.84284210205078 0.0
2IVU A X-ray 2.5 2 A 0.6341401 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 63.46196746826172 0.0
809 809 TYR C 0.97 87.9951400756836 0.0
900 900 TYR - 0.96 80.9068832397461 0.0
981 981 TYR H 1.0 41.48078155517578 0.0
2X2M A X-ray 2.5 2 B 0.77859384 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 58.63609313964844 0.0
809 809 TYR C 0.97 88.38536071777344 0.0
900 900 TYR C 0.96 86.64373779296875 0.0
981 981 TYR H 1.0 37.997886657714844 0.0
2IVT A X-ray 2.6 2 A 0.6687435 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 56.25413513183594 0.0
809 809 TYR C 0.97 91.61370086669922 0.0
900 900 TYR C 0.96 164.93484497070312 0.0
981 981 TYR H 1.0 40.45587158203125 0.0
2X2K A X-ray 2.6 2 A 0.5731538 806, 809, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 59.660736083984375 0.0
809 809 TYR C 0.97 89.35869598388672 0.0
900 900 TYR - 0.96 72.30731201171875 0.0
981 981 TYR H 1.0 39.9781379699707 0.0
4CKI A X-ray 2.12 2 A 0.8481818 806, 809, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 60.658935546875 0.0
809 809 TYR C 0.97 80.61398315429688 0.0
981 981 TYR H 1.0 38.994232177734375 0.0
6FEK A X-ray 2.3 2 A 1.0 806, 809, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 55.17501449584961 0.0
809 809 TYR C 0.97 89.2767333984375 0.0
981 981 TYR H 1.0 37.012516021728516 0.0
5AMN A X-ray 2.57 2 A 0.60369015 806, 809, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 67.90252685546875 0.0
809 809 TYR C 0.97 85.2388916015625 0.0
981 981 TYR H 1.0 39.18359375 0.0
5FM3 A X-ray 2.95 2 A 0.86128026 806, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 50.34503936767578 0.0
900 900 TYR C 0.96 77.1701889038086 0.0
981 981 TYR H 1.0 35.98500442504883 0.0
5FM2 A X-ray 3.3 2 A 0.8504323 806, 900, 981
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
806 806 TYR C 1.0 49.09701156616211 0.0
900 900 TYR C 0.96 72.95599365234375 0.0
981 981 TYR H 1.0 36.66809844970703 0.0
4UX8 A EM 24.0 Monomer C 0.0 291
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
105 105 SER H 0.81 7.911789417266846 0.0
152 152 THR C 0.55 85.14761352539062 0.0
159 159 SER H 0.74 71.9853744506836 0.0
291 291 THR E 0.83 23.371946334838867 0.0
2X2U A X-ray 2.0 2 [SO4]A:1276 0.15063801
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
105 105 SER H 0.81 7.47648286819458 0.0
152 152 THR C 0.55 85.70393371582031 0.0
159 159 SER H 0.74 66.19607543945312 0.0

Mutations

Showing 98 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
20 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
32 S L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
40 L P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
64 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
67 R H Disease Congenital central hypoventilation syndrome (CCHS) [MIM:209880]
77 R C Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
93 G S Unclassified Hirschsprung disease 1 (HSCR1) [MIM:142623]
114 R C Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
142 C S Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
145 V G Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
155 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
157 C Y Unclassified Hirschsprung disease 1 (HSCR1) [MIM:142623]
163 R Q Unclassified A colorectal adenocarcinoma sample
174 F S Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
175 R P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
180 R P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
197 C Y Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
198 P T Unclassified
231 R H Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
251 E K Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
278 T P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
287 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
292 V M Unclassified
300 D N Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
313 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
316 S I Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
330 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
339 S L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
353 D Y Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
359 N K Unclassified Hirschsprung disease 1 (HSCR1) [MIM:142623]
360 R W Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
376 V A Unclassified
393 F L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
394 N K Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
397 V M Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
399 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
412 V M Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
423 G R Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
432 A E Disease Congenital central hypoventilation syndrome (CCHS) [MIM:209880]
475 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
480 E K Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
489 D N Polymorphism
593 G E Unclassified A colorectal cancer sample
595 E Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
600 R Q Polymorphism
609 C G Disease Multiple neoplasia 2A (MEN2A) [MIM:171400]
611 C W Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
618 C S Disease Multiple neoplasia 2A (MEN2A) [MIM:171400]
620 C W Disease Multiple neoplasia 2A (MEN2A) [MIM:171400]
626 Q K Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
630 C S Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
631 D G Unclassified Thyroid carcinoma
634 C W Disease Multiple neoplasia 2A (MEN2A) [MIM:171400]
639 A G Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
640 A G Disease Multiple neoplasia 2A (MEN2A) [MIM:171400]
641 A G Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
679 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
690 S P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
691 G S Polymorphism
694 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
749 R T Polymorphism
762 E Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
765 S P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
767 S R Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
768 E D Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
778 V I Unclassified
783 N S Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
790 L F Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
791 Y F Disease Pheochromocytoma (PCC) [MIM:171300]
804 V L Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
813 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
826 Y S Polymorphism
830 G R Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
844 R L Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
873 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
883 A F Disease Multiple neoplasia 2B (MEN2B) [MIM:162300]
891 S A Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
893 F L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
894 G S Unclassified
897 R Q Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
907 K T Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
918 M T Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
921 E K Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
922 S F Disease Medullary thyroid carcinoma (MTC) [MIM:155240]
946 T M Disease Multiple neoplasia 2B (MEN2B) [MIM:162300]
961 F L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
972 R G Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
973 P L Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
980 M T Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
982 R C Polymorphism
1039 P L Disease Congenital central hypoventilation syndrome (CCHS) [MIM:209880]
1049 P L Unclassified
1052 L V Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
1061 L P Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
1062 Y C Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
1064 M T Disease Hirschsprung disease 1 (HSCR1) [MIM:142623]
1067 P S Unclassified
1112 F Y Unclassified A bladder transitional cell carcinoma sample