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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 28 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
70 PhosphoS UP Combined
76 PhosphoT PRIDE yes
82 PhosphoS PRIDE
83 PhosphoT PRIDE
346 PhosphoS PRIDE yes
385 PhosphoS PRIDE yes
970 PhosphoY PRIDE yes
1230 PhosphoS UP, PRIDE Similarity yes
1712 PhosphoT PRIDE yes
1903 PhosphoS PRIDE yes
2042 PhosphoT PRIDE yes
2517 PhosphoY PRIDE yes
2967 PhosphoY PRIDE
2968 PhosphoT PRIDE
3081 PhosphoT PRIDE yes
3082 PhosphoS PRIDE yes
3379 PhosphoY PRIDE yes
3729 PhosphoS PRIDE yes
3768 PhosphoT PRIDE
3769 PhosphoT PRIDE
4162 PhosphoS UP Combined
4234 PhosphoS PRIDE yes
4357 PhosphoY PRIDE yes
4366 PhosphoT UP, PRIDE Combined yes
4368 PhosphoS UP, PRIDE Combined yes
4369 PhosphoT PRIDE yes
4370 PhosphoS PRIDE yes
4498 PhosphoS PRIDE yes

3D structure is not available

Display Settings

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 29 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
76 68 81 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
82 82 96 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
83 82 96 2 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
346 324 354 23 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD005366 1 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
385 380 394 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
970 964 979 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
1230 1227 1242 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD006482 2 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
1712 1698 1715 15 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000218 1 System-level analysis of cancer and stomal cell specific proteomes reveals extensive reprogramming of phosphorylation networks by tumor microenvironment Homo sapiens (Human),Mus musculus (Mouse) COMPLETE 2014-04-01 Epithelial cell, colon
1903 1900 1912 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
2042 2038 2046 5 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
2517 2512 2519 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
2967 2963 2977 5 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 2 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
2968 2963 2977 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 2 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
3081 3077 3088 5 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
3081 3079 3088 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
3082 3079 3088 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD002286 1 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 -
3379 3370 3384 10 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001565 2 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
3729 3728 3733 2 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
3768 3760 3782 9 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
3769 3760 3782 10 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
4234 4229 4237 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
4234 4231 4244 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
4357 4346 4363 12 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001565 1 Evaluation of phospho-tyrosine antibodies for label-free phosphoproteomics Homo sapiens (Human) PARTIAL 2015-12-09 colon,brain
4366 4366 4378 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 6 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
4368 4364 4378 5 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD006482 3 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD005366 1 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
4368 4366 4378 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD006482 3 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD000680 3 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
4369 4366 4378 4 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001060 12 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell
PXD002394 4 Proteomic and phosphoproteomic analysis of cisplatin resistance in patient derived serous ovarian cancer Homo sapiens (Human) PARTIAL 2017-05-02 cell suspension culture -
4370 4364 4378 7 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004252 1 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell
4498 4488 4505 11 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD002057 2 Proteomic analysis identifies novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy Homo sapiens (Human) COMPLETE 2016-02-22 cell culture

Structures

Showing 4 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
5NUG A EM 3.799999952316284 Monomer B 0.0 1712, 1903, 2042, 2517, 2967, 2968, 3081, 3082, 3729, 3768, 3769, 4162, 4234, 4498
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
1618 1618 TYR H 1 10.61662483215332 0.0
1712 1712 THR H 1 0.0 0.0
1903 1903 SER E 0.92 6.110105514526367 0.0
2042 2042 THR C 1 40.01023483276367 0.0
2428 2428 THR C 1 54.6204719543457 0.0
2517 2517 TYR H 1 36.020267486572266 0.0
2967 2967 TYR C 0.92 14.586700439453125 0.0
2968 2968 THR C 0.91 79.89659881591797 0.0
3081 3081 THR H 0.93 15.304339408874512 0.0
3082 3082 SER C 0.91 1.1749738454818726 0.0
3729 3729 SER H 1 38.96113586425781 0.0
3768 3768 THR H 1 75.1152114868164 0.0
3769 3769 THR H 1 36.68252182006836 0.0
4162 4162 SER H 1 71.68809509277344 0.0
4234 4234 SER C 0.86 42.637630462646484 0.0
4498 4498 SER C 0.63 120.68932342529297 0.0
6F1T e EM 3.5 Monomer f 0.0 70, 76, 82, 83, 346, 385
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
70 70 SER C 0.52 69.7425765991211 0.0
76 76 THR C 0.56 23.885652542114258 12.134209632873535
82 82 SER E 0.6 36.659751892089844 0.0
83 83 THR C 0.58 54.485740661621094 0.0
346 346 SER C 1 36.23041534423828 0.0
385 385 SER H 1 20.81252098083496 0.0
390 390 SER H 0.91 66.29743194580078 0.0
722 722 SER C 0.86 26.01468276977539 0.0
6F1U f EM 3.4000000953674316 Monomer h 0.0 346, 385
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
346 346 SER C 1 69.69222259521484 0.0
385 385 SER H 1 0.0 0.0
390 390 SER H 0.91 54.39372634887695 0.0
722 722 SER E 0.86 51.38935470581055 0.0
6F1V f EM 3.4000000953674316 Monomer m 0.0
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
722 722 SER E 0.86 51.38935470581055 0.0

Mutations

Showing 30 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
94 E K Unclassified
129 K I Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
142 E A Polymorphism
264 R L Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
306 H R Disease Charcot-Marie-Tooth disease 2O (CMT2O) [MIM:614228]
584 I L Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
598 R C Disease Charcot-Marie-Tooth disease 2O (CMT2O) [MIM:614228]
671 K E Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
776 P L Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
970 Y C Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
1132 G E Disease Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1) [MIM:158600]
1194 Q R Disease Charcot-Marie-Tooth disease 2O (CMT2O) [MIM:614228]
1250 V L Polymorphism
1518 E K Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
1567 R Q Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
1962 R C Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
2247 V M Polymorphism
3048 E K Disease Charcot-Marie-Tooth disease 2O (CMT2O) [MIM:614228]
3241 K T Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
3336 K N Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
3344 R Q Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
3384 R Q Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
3822 H P Disease Mental retardation, autosomal dominant 13 (MRD13) [MIM:614563]
3902 D N Polymorphism
4029 H Q Polymorphism
4143 R C Polymorphism
4285 A S Polymorphism
4421 A T Polymorphism
4507 I S Polymorphism
4603 S G Polymorphism