Welcome to Scop3P

Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

  • Zoom in and zoom out (both with mouse and buttons on the right top corner) to see modificationson the protein
  • Slide the chart to see other modifications (both with mouse and buttons on the right topcorner)
  • Hover on the modification to see more information and position on the structure.
PDB 
 AlphaFold
Phospho-sites

Showing 7 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
227 PhosphoY PRIDE yes
231 PhosphoT PRIDE yes
232 PhosphoS UP, PRIDE Combined yes
293 PhosphoS UP, PRIDE Experimental
295 PhosphoS UP, PRIDE Similarity
300 PhosphoS UP, PRIDE Experimental
301 PhosphoY UP, PRIDE Similarity

3D structure is not available

Display Settings

Hover over to see the values, zoom (in/out) or drag by using the mouse pointer.

Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 11 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
227 227 235 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 17 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
231 216 235 16 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
231 227 235 5 6
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004252 1 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD000612 5 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD002286 36 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD006482 6 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD005366 5 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
231 227 244 5 3
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD005366 3 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
232 227 235 6 13
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004252 18 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD003531 20 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD004940 1 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD001333 2 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD006482 15 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
PXD002286 117 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD005366 115 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD001374 1 Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling Homo sapiens (Human) PARTIAL 2015-08-24 HeLa cell -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD001550 3 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD000680 4 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
PXD000836 1 HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies Homo sapiens (Human) PARTIAL 2014-05-22 lung -
PXD000612 33 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
232 227 244 6 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 3 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
293 289 302 5 15
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004252 30 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD001060 20 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD004940 2 Performance of the Orbitrap Fusion Lumos Tribrid in single-shot analyses of human samples Homo sapiens (Human) PARTIAL 2017-03-09 HeLa cell -
PXD003531 343 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD001333 15 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD005366 314 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
PXD002394 25 Proteomic and phosphoproteomic analysis of cisplatin resistance in patient derived serous ovarian cancer Homo sapiens (Human) PARTIAL 2017-05-02 cell suspension culture -
PXD004452 41 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD001550 30 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD001374 8 Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling Homo sapiens (Human) PARTIAL 2015-08-24 HeLa cell -
PXD003198 1 Characterisation of pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling Homo sapiens (Human) PARTIAL 2016-06-09 pancreatic cell line -
PXD000836 54 HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies Homo sapiens (Human) PARTIAL 2014-05-22 lung -
PXD000612 18 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD001546 35 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD004415 2 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte -
295 289 302 7 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD003531 3 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD005366 5 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD003198 1 Characterisation of pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling Homo sapiens (Human) PARTIAL 2016-06-09 pancreatic cell line -
295 289 311 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001374 2 Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling Homo sapiens (Human) PARTIAL 2015-08-24 HeLa cell
300 289 302 12 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD005366 14 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture
PXD002394 1 Proteomic and phosphoproteomic analysis of cisplatin resistance in patient derived serous ovarian cancer Homo sapiens (Human) PARTIAL 2017-05-02 cell suspension culture -
PXD001550 6 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
301 289 302 13 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003198 3 Characterisation of pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling Homo sapiens (Human) PARTIAL 2016-06-09 pancreatic cell line

Structures

Showing 7 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
2OZL A X-ray 1.899999976158142 4 B 0.20518327
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
227 198 TYR E 0.87 20.2637939453125 0.0
231 202 THR E 1.0 45.15023422241211 0.0
232 203 SER E 1.0 19.50791358947754 0.0
287 258 TYR C 1.0 2.0031447410583496 0.0
295 266 SER C 1.0 90.9505844116211 0.0
300 271 SER C 1.0 109.29143524169922 0.0
301 272 TYR C 1.0 51.04688262939453 0.0
1NI4 A X-ray 1.9500000476837158 4 B 0.20700239
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
227 198 TYR E 0.87 22.557031631469727 0.0
231 202 THR E 1.0 43.5295524597168 0.0
232 203 SER E 1.0 22.531084060668945 0.0
287 258 TYR C 1.0 1.3286243677139282 0.0
293 264 SER C 1.0 14.570303916931152 0.0
295 266 SER C 1.0 100.62297058105469 0.0
300 271 SER C 1.0 106.74771118164062 0.0
301 272 TYR C 1.0 50.15580368041992 0.0
3EXE A X-ray 1.9800000190734863 4 B 0.20546713
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
227 198 TYR E 0.87 18.720050811767578 0.0
231 202 THR E 1.0 47.17521286010742 0.0
232 203 SER E 1.0 18.605064392089844 0.0
287 258 TYR C 1.0 1.674797534942627 0.0
293 264 SER C 1.0 10.554624557495117 0.0
295 266 SER C 1.0 101.28407287597656 0.0
300 271 SER C 1.0 109.6397476196289 0.0
301 272 TYR C 1.0 49.21040725708008 0.0
3EXI A X-ray 2.200000047683716 4 [K]B:1002 0.17000885
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
287 258 TYR C 1.0 143.53787231445312 0.0
3EXH A X-ray 2.440000057220459 4 B 0.20508976
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
227 198 TYR C 0.87 58.90321731567383 0.0
287 258 TYR C 1.0 0.9931106567382812 0.0
293 264 SER C 1.0 113.02928161621094 0.0
295 266 SER C 1.0 112.1310043334961 0.0
301 272 TYR H 1.0 122.53791809082031 0.0
3EXF A X-ray 3.0 4 B 0.20026492
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
227 198 TYR E 0.87 18.0428466796875 0.0
231 202 THR E 1.0 43.08369827270508 0.0
287 258 TYR C 1.0 2.339212417602539 0.0
293 264 SER C 1.0 14.651047706604004 0.0
295 266 SER C 1.0 95.37680053710938 0.0
301 272 TYR C 1.0 53.250728607177734 0.0
3EXG 1 X-ray 3.009999990463257 4 2 0.23430105
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
287 258 TYR C 1.0 93.21436309814453 0.0

Mutations

Showing 21 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
10 R P Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
72 R C Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
113 H D Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
136 A T Disease
162 G R Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
167 V M Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
199 A T Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
205 F L Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
210 M V Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
217 P L Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
231 T A Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
243 Y N Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
258 D A Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
263 R Q Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
282 M L Polymorphism
288 R H Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
292 H L Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
302 R C Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
315 D N Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]
333 E D Polymorphism
378 R H Disease Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]