Welcome to Scop3P

Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

  • Zoom in and zoom out (both with mouse and buttons on the right top corner) to see modificationson the protein
  • Slide the chart to see other modifications (both with mouse and buttons on the right topcorner)
  • Hover on the modification to see more information and position on the structure.
PDB 
 AlphaFold
Phospho-sites

Showing 4 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
133 PhosphoY PRIDE yes
166 PhosphoS PRIDE yes
709 PhosphoS PRIDE yes
716 PhosphoS PRIDE yes

3D structure is not available

Display Settings

Hover over to see the values, zoom (in/out) or drag by using the mouse pointer.

Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 4 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
133 128 135 6 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 4 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
166 163 186 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
709 702 713 8 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD002286 6 Phospo-proteomic profiling of Castration Resistant Prostate Cancer Homo sapiens (Human) PARTIAL 2016-08-19 - -
PXD004452 2 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
716 716 736 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture

Structures

Showing 1 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
2QV2 A X-ray 2.4000000953674316 2 A 1.0
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
709 150 SER C 0.39 74.900390625 0.0
716 157 SER C 0.73 37.97958755493164 0.0

Mutations

Showing 38 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
242 F S Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
274 I T Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
277 Q R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
318 R C Disease Dent disease 2 (DD2) [MIM:300555]
337 R C Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
354 N H Disease Dent disease 2 (DD2) [MIM:300555]
357 G E Unclassified Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
361 R I Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
372 V G Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
373 N Y Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
374 S F Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
375 H Y Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
414 H R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
421 G E Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
424 N D Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
451 D N Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
457 R G Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
463 F S Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
468 E K Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
479 Y C Disease Dent disease 2 (DD2) [MIM:300555]
493 R W Disease Dent disease 2 (DD2) [MIM:300555]
495 P L Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
498 C Y Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
499 D H Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
500 R G Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
503 W R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
508 V D Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
513 Y C Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
522 S R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
524 H R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
526 P L Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
533 I S Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
591 N K Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
768 I N Unclassified Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
797 A P Unclassified Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
799 P L Disease Dent disease 2 (DD2) [MIM:300555]
801 P L Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]
891 L R Disease Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]