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Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

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PDB 
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Phospho-sites

Showing 13 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
197 PhosphoY PRIDE yes
215 PhosphoT PRIDE yes
226 PhosphoY PRIDE yes
265 PhosphoT PRIDE yes
317 PhosphoT UP Combined
374 PhosphoT UP, PRIDE Combined yes
402 PhosphoS UP, PRIDE Combined yes
419 PhosphoS PRIDE yes
431 PhosphoT PRIDE yes
450 PhosphoS PRIDE yes
461 PhosphoS PRIDE yes
462 PhosphoY PRIDE yes
717 PhosphoT PRIDE yes

3D structure is not available

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Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 12 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
197 194 202 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 9 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
215 212 219 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
226 220 244 7 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell
265 261 277 5 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD003531 1 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell
374 372 389 3 4
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture -
PXD004415 1 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
402 400 415 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004415 1 Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells Homo sapiens (Human) COMPLETE 2017-05-11 T lymphocyte
PXD001374 1 Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling Homo sapiens (Human) PARTIAL 2015-08-24 HeLa cell -
419 416 423 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 5 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
431 424 436 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004452 1 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon
450 450 457 1 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 12 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
461 459 467 3 2
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD001333 3 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell -
462 459 470 4 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001333 2 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
717 690 727 28 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000680 1 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell

Structures

Showing 12 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
5YEG B X-ray 2.0 3 F 1.0 374, 374, 402, 402, 419, 419, 431, 431, 450, 450, 461, 461, 462, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 90.14431762695312 0.0
374 374 THR H 1 84.3828353881836 0.0
402 402 SER H 1 85.99723052978516 0.0
402 402 SER H 1 82.32296752929688 0.0
419 419 SER H 1 53.44075012207031 0.0
419 419 SER H 1 53.88368225097656 0.0
431 431 THR C 1 63.20411682128906 0.0
431 431 THR C 1 62.95765686035156 0.0
450 450 SER H 1 80.16845703125 1.8417431116104126
450 450 SER H 1 68.06877899169922 1.1047914028167725
461 461 SER C 1 46.87168884277344 0.0
461 461 SER C 1 52.6475715637207 0.0
462 462 TYR C 1 138.1720733642578 0.0
462 462 TYR C 1 150.60415649414062 0.0
5T0U A X-ray 3.200000047683716 3 C 1.0 317, 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
317 317 THR C 1 71.82532501220703 0.0
319 319 THR C 1 67.56037139892578 0.0
374 374 THR H 1 81.44550323486328 0.0
402 402 SER H 1 79.27862548828125 0.0
419 419 SER H 1 59.460731506347656 0.0
431 431 THR C 1 64.62789916992188 0.0
450 450 SER H 1 79.15572357177734 4.659712314605713
461 461 SER C 1 79.42459869384766 0.0
462 462 TYR C 1 187.03164672851562 0.0
5KKQ A X-ray 1.7400000095367432 3 C 1.0 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 90.0666275024414 0.0
402 402 SER H 1 83.55941009521484 0.0
419 419 SER H 1 58.3000602722168 0.0
431 431 THR C 1 63.7401008605957 0.0
450 450 SER H 1 80.79109954833984 1.9672913551330566
461 461 SER C 1 105.49034881591797 0.0
462 462 TYR C 1 108.424560546875 0.0
5T00 A X-ray 2.190000057220459 3 C 1.0 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 87.76080322265625 0.0
402 402 SER H 1 79.99742889404297 0.0
419 419 SER H 1 55.93528366088867 0.0
431 431 THR C 1 65.00819396972656 0.0
450 450 SER H 1 78.93243408203125 5.644227504730225
461 461 SER C 1 103.94792175292969 0.0
462 462 TYR C 1 143.92202758789062 0.0
5YEH A X-ray 2.3299999237060547 6 C 0.99340045 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 107.22077178955078 0.0
402 402 SER H 1 85.27689361572266 0.0
419 419 SER H 1 52.22816467285156 0.0
431 431 THR C 1 66.53760528564453 0.0
450 450 SER H 1 83.06525421142578 0.24676232039928436
461 461 SER C 1 38.556182861328125 0.0
462 462 TYR C 1 94.0608139038086 0.0
5UND A X-ray 2.549999952316284 3 [ZN]A:606 0.6940714 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 100.8585433959961 0.0
402 402 SER H 1 81.46844482421875 0.0
419 419 SER H 1 58.09807205200195 0.0
431 431 THR C 1 62.39983367919922 0.0
450 450 SER H 1 81.07312774658203 0.0
461 461 SER C 1 47.809574127197266 0.0
462 462 TYR C 1 162.1653289794922 0.0
5YEF A X-ray 2.809999942779541 3 D 1.0 374, 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 79.205078125 0.0
402 402 SER H 1 83.45941162109375 0.0
419 419 SER H 1 52.454620361328125 0.0
431 431 THR C 1 55.90869140625 0.0
450 450 SER H 1 76.13569641113281 1.9649068117141724
461 461 SER C 1 46.47639465332031 0.0
462 462 TYR E 1 157.25489807128906 0.0
5K5I A X-ray 2.190000057220459 3 C 0.3683005 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
402 402 SER H 1 80.46852111816406 0.0
419 419 SER H 1 42.76413345336914 0.0
431 431 THR C 1 59.6698112487793 0.0
450 450 SER H 1 81.6175765991211 2.3295822143554688
461 461 SER C 1 52.51164245605469 0.0
462 462 TYR C 1 145.3662872314453 0.0
5K5J A X-ray 2.2899999618530273 3 C 0.5443812 402, 419, 431, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
402 402 SER H 1 83.38192749023438 0.0
419 419 SER H 1 56.485660552978516 0.0
431 431 THR C 1 59.140716552734375 0.0
450 450 SER H 1 80.65796661376953 1.5925031900405884
461 461 SER C 1 40.799583435058594 0.0
462 462 TYR C 1 152.31759643554688 0.0
5K5H A X-ray 3.109999895095825 3 B 1.0 374, 402, 419, 431, 450
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
374 374 THR H 1 91.48273468017578 0.0
402 402 SER C 1 61.77893829345703 0.0
419 419 SER H 1 53.07522201538086 0.0
431 431 THR C 1 63.90475082397461 0.0
450 450 SER H 1 68.54365539550781 4.682814121246338
5YEL A X-ray 2.9600000381469727 3 F 1.0 419, 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
419 419 SER H 1 59.1963996887207 0.0
450 450 SER H 1 87.12783813476562 1.7141724824905396
461 461 SER C 1 45.791202545166016 0.0
462 462 TYR E 1 154.1918487548828 0.0
5K5L E X-ray 3.119999885559082 3 A 0.26071712 450, 461, 462
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
450 450 SER H 1 81.36353302001953 0.0
461 461 SER C 1 51.8697624206543 0.0
462 462 TYR C 1 151.7895965576172 0.0

Mutations

Showing 8 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
278 R C Unclassified
339 R W Unclassified A Wilms' tumor
342 R H Unclassified
344 K E Unclassified A breast tumor
345 H R Unclassified A prostate tumor
365 K T Unclassified
448 R Q Unclassified A Wilms' tumor
567 R W Disease Mental retardation, autosomal dominant 21 (MRD21) [MIM:615502]