Welcome to Scop3P

Search for the desired protein with Uniprot accession, protein name/keyword, ProteomeXchange ID or PDB id

Ex.: O00571, ddx3x (keyword), ATP-dependent RNA helicase DDX3X, PXD000680 or 3JRV

  • Zoom in and zoom out (both with mouse and buttons on the right top corner) to see modificationson the protein
  • Slide the chart to see other modifications (both with mouse and buttons on the right topcorner)
  • Hover on the modification to see more information and position on the structure.
PDB 
 AlphaFold
Phospho-sites

Showing 6 results

Swiss-Prot Position Modification Source Evidence Singly phosphorylated
2 PhosphoS PRIDE
3 PhosphoT PRIDE
19 PhosphoS UP, PRIDE Combined yes
28 PhosphoS UP Similarity
128 PhosphoY UP, PRIDE Combined yes
133 PhosphoY PRIDE yes

3D structure is not available

Display Settings

Hover over to see the values, zoom (in/out) or drag by using the mouse pointer.

Phosphorylated amino acids are colored red on the inner ring.

The first amino acid of the protein sequence is colored darker on each ring.

Phospho peptides

Showing 6 results

Sequence Modified position (Swiss-Prot) Peptide start Peptide end Modified position (Peptide) Number of projects
2 1 16 2 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
3 1 16 3 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD001333 1 Anion-Exchange Chromatography of Tryptic and Phosphopeptides: WAX vs. SAX and AEX vs. ERLIC Homo sapiens (Human) PARTIAL 2015-04-23 HeLa cell
19 17 25 3 10
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD004252 3 Modulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy Homo sapiens (Human) PARTIAL 2016-08-03 cell culture -
PXD001060 10 Fe-IMAC column based phospho enrichment Homo sapiens (Human) PARTIAL 2015-08-19 Epithelial cell -
PXD000612 2 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
PXD001546 1 Reproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD003531 12 Proteomics of Primary cells derived from Ovarian Cancer Homo sapiens (Human) PARTIAL 2017-04-03 primary cell -
PXD006482 9 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney -
PXD005366 39 Robust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons Homo sapiens (Human),Rattus norvegicus (Rat) PARTIAL 2016-12-14 cell culture -
PXD004452 2 HeLa proteome of 12,250 protein-coding genes Homo sapiens (Human) PARTIAL 2017-06-12 liver,colon -
PXD001550 10 Human CRC cell line baseline phosphoproteomics Homo sapiens (Human) PARTIAL 2015-04-15 cell culture -
PXD000680 14 Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination Homo sapiens (Human) COMPLETE 2014-04-15 HeLa cell,HEK-293 cell -
19 18 25 2 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD006482 1 Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer Homo sapiens (Human) COMPLETE 2017-09-01 kidney
128 121 129 8 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 1 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture
133 132 143 2 1
ProteomeXchange accession Peptide frequency Project Title Species Submission Type Publication Date Tissues USI
PXD000612 3 Ultra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling Homo sapiens (Human) PARTIAL 2014-08-06 cell culture

Structures

Showing 1 results

PDB id Chain Method Resolution Stoichiometry Interfacing Molecule/Chain Complex Formation Significance Score (CSS) P-sites View Structure
3I2B A X-ray 2.299999952316284 6 [NI]A:146 0.63772446 19, 28, 128, 133
Swiss-Prot position PDB position Residue Secondary Structure Conserved Scale Accessible surface area Buried surface area
19 19 SER E 0.7 59.639827728271484 0.0
21 21 SER E 0.88 34.80974578857422 0.0
28 28 SER C 0.83 21.669870376586914 0.0
128 128 TYR E 0.79 55.437679290771484 0.0
133 133 TYR E 0.76 51.38883972167969 0.0

Mutations

Showing 21 results

Swiss-Prot Position Amino acid (Wild type) Amino acid (Variant) Variant Type Disease
16 R C Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
25 R G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
26 L F Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
35 E G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
36 N K Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
47 N D Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
52 N S Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
56 V M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
67 T M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
70 V D Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
87 P S Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
96 D N Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
97 V M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
99 Y C Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
100 F V Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
106 T M Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
114 I V Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
116 D G Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
124 V L Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
129 K E Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]
136 D V Disease Hyperphenylalaninemia, BH4-deficient, A (HPABH4A) [MIM:261640]