LNCASO is an antisense oligonucleotide (ASO) design tool specifically geared towards long non-coding RNAs (lncRNA).

Several features of both the ASO and the target RNA have an effect on the observed knockdown. We trained a generalized additive model on the affinity of the oligo for the target, the secondary structure of the target RNA and dimerization of the oligo that shows 78% accuracy in predicting functional ASOs.

Manuscript currently in editorial process